Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

GK-101 2-(chloroamino)ethanoic acid

Synonyms: AG-K-07419, AC1Q3VFP, CTK1C2512, AR-1K6597, AR-1K6598, ...

Scully, F.E. et al., Goldman, M. et al., Zgiczyński, J.M. et al., Kronman, J.H. et al., Kronman, J.H. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on N-Chloroglycine

After in vitro chlorination of stomach fluid, three chloramino acids, N-chloroglycine, either N-chloroleucine or N-chloroisoleucine, and N-chlorophenylalanine, were identified by GC/MS analysis of dansylated methyl ester derivatives [1].
A comparative in vitro study of GK-101 and GK-101E in caries removal [2].
Study of the effects of GK-101 (N-monochloroglycine on the dental pulp [3].
The chlorination of glycine by the myeloperoxidase-H2O2-Cl- system at acidic pH values yielded N-monochloroglycine and a mixture of HCN and ClCN [4].
A chemical evaluation of collagen and hydroxyproline after treatment with GK-101 (N-Chloroglycine) [5].

Anatomical context of N-Chloroglycine

The application of GK-101 to carious dentin softens the first or outer layer which contains denatured collagen [6].

Analytical, diagnostic and therapeutic context of N-Chloroglycine

Electron microscopic study of altered collagen structure after treatment with N-monochloro-DL-2-aminobutyrate (GK-101 E) [7].
The effects of N-monochloroglycine (NMG) solutions on the structure of collagen were studied by transmission electron microscopy [8].
In the double-blind study, the efficacy, as shown by ratings for caries removal, of GK-101 applied under pressure was significantly greater than that of the placebo solution of normal saline (P less than 0.01) [9].

References

Identification of organic N-chloramines in vitro in stomach fluid from the rat after chlorination. Scully, F.E., Mazina, K.E., Ringhand, H.P., Chess, E.K., Campbell, J.A., Johnson, J.D. Chem. Res. Toxicol. (1990) [Pubmed]
A comparative in vitro study of GK-101 and GK-101E in caries removal. Schutzbank, S.G., Galaini, J., Kronman, J.H., Goldman, M., Clark, R.E. J. Dent. Res. (1978) [Pubmed]
Study of the effects of GK-101 (N-monochloroglycine on the dental pulp. Kronman, J.H., Goldman, M., Cataldo, E. J. Dent. Res. (1976) [Pubmed]
Hydrogen cyanide and cyanogen chloride formation by the myeloperoxidase-H2O2-Cl- system. Zgiczyński, J.M., Stelmaszyńska, T. Biochim. Biophys. Acta (1979) [Pubmed]
A chemical evaluation of collagen and hydroxyproline after treatment with GK-101 (N-Chloroglycine). Habib, C.M., Kronman, J., Goldman, M. Pharmacology and therapeutics in dentistry. (1975) [Pubmed]
Effect of a carious dentin softener on the dentin and pulp. Kurosaki, N., Sato, Y., Iwaku, M., Fusayama, T. The Journal of prosthetic dentistry. (1977) [Pubmed]
Electron microscopic study of altered collagen structure after treatment with N-monochloro-DL-2-aminobutyrate (GK-101 E). Kronman, J.H., Goldman, M., Habib, C.M., Mengel, L. J. Dent. Res. (1979) [Pubmed]
Electron microscopic evaluation of altered collagen structure induced by N-monochloroglycine (GK-101). Kronman, J.H., Goldman, M., Habib, C.M., Mengel, L. J. Dent. Res. (1977) [Pubmed]
A preliminary report on a chemomechanical means of removing caries. Goldman, M., Kronman, J.H. Journal of the American Dental Association (1939) (1976) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.