High impact information on H 35-25

• Similarly, portal hypertensive rats receiving beta-blockade with H35-25, an experimental beta-blocker, demonstrated a 49% reduction in portal blood flow accompanied by only a 14% reduction in portal pressure, also disproportionately low because of a complicating 77% rise in portal-collateral vascular resistance [1].
• The field-stimulus-induced increase in cyclic AMP was abolished by the beta 1-adrenergic receptor antagonist, metoprolol, but persisted in the presence of the beta 2-adrenergic antagonist, H35/25 [2].
• 1. Characterization of the beta-adrenoceptors mediating inhibition of gastric acid secretion in the conscious Heidenhain pouch dog has been investigated by determination of the effects of propranolol, (+)-propranolol, practolol and H35/25 on salbutamol and isoprenaline-induced inhibition of gastric acid secretion [3].
• 5 H 35/25 ((I-(4-methylphenyl)-2-isopropyl aminopropanol) hydrochloride, 3 mg/kg) antagonized the effects of isoprenaline on blood pressure, glucose and lactate selectively [4].
• Metoprolol and high concentrations of H35/25 further contracted large coronary arteries partially contracted by 25 mM potassium [5].

Biological context of H 35-25

• Using the combination of metoprolol and H35/25 the resulting dose-ratio for adrenaline was multiplicative demonstrating again the presence of two binding sites [6].

Anatomical context of H 35-25

• Propranolol and the beta 2-adrenoceptor antagonists ICI 118,551 and H 35/25 induced a marked extrusion of the incisor, probably due to reduced vasodilator tone in periodontal postcapillary blood vessels [7].
• The pA2-values for H35/25 where the highest when compared with those of atrium or ileum [6].
• Results obtained with the beta-receptor antagonists propranolol, practolol and H35/25 suggest that the depression in skeletal muscle contractility is due to beta2-adrenoreceptor stimulation [8].

Associations of H 35-25 with other chemical compounds

• Metoprolol and high concentrations of H35/25 have a direct contractile effect in large porcine coronary artery that is not mediated by alpha-adrenergic, muscarinic, histaminergic, or serotonergic receptors but requires verapamil-sensitive calcium [5].
• The stimulatory effects of dimaprit were not reversed by the H2-receptor antagonist, cimetidine, nor by the beta-receptor antagonists metoprolol and H 35/25 [9].

Analytical, diagnostic and therapeutic context of H 35-25

• 4. Denervation did not alter the antagonist activity of beta-adrenoreceptor blockers propranolol (nonselective) and metoprolol (beta 1-blocker) against isoprenaline or of H 35/25 (beta 2-blocker) against salbutamol [10].

References