Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL513308 [(2R,3S,5R)-5-(6-aminopurin- 9-yl)-2...

Synonyms: SureCN3502762, CHEBI:580387, AC1L4ZSF, AR-1E1089, 1cs4, ...

Legrand, A.B. et al., Engelmann, B. et al., Johnson, R.A. et al.

Engelmann, Zieseniss, Brand, Page, Lentschat, Ulmer, Gerlach,

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High impact information on 2'-Deoxy-3'-adenosine monophosphate

Inhibition of adenylyl cyclase by pretreatment with 2'-deoxy-3'-adenosine monophosphate partially reversed the inhibition of TF activity promoted by lysoPC [1].
These resulted in IC50 values for (2',5'dideoxy-adenosine (2',5'-dd-Ado) and 2'-deoxy-3'-AMP of approximately 1-2 microM [2].
The natural nucleotide 2'-deoxy-3'-AMP was a strong inhibitor in aortic cell types (as in pulmonary arterial endothelial cells) and may possibly act as a modulator of adenylate cyclase in these cells [3].

References

Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine. Engelmann, B., Zieseniss, S., Brand, K., Page, S., Lentschat, A., Ulmer, A.J., Gerlach, E. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
Cation and structural requirements for P site-mediated inhibition of adenylate cyclase. Johnson, R.A., Yeung, S.M., Stübner, D., Bushfield, M., Shoshani, I. Mol. Pharmacol. (1989) [Pubmed]
Effects of adenosine and analogs on adenylate cyclase activity in cultured bovine aortic endothelial cells. Legrand, A.B., Narayanan, T.K., Ryan, U.S., Aronstam, R.S., Catravas, J.D. Biochem. Pharmacol. (1990) [Pubmed]

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