Chemical Compound Review:
AG-E-37499
(3R,5S,7R,8S,9S,10S,12S,13R,14 S)-17-[(2R)...
Synonyms:
HMDB00524, CTK4D9872, AC1L50JB, 18866-87-0, Cholestane-3,7,12,25-tetrol, ...
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- The results demonstrate that microsomal 25- and 26-hydroxylations of 5beta-cholestane-3alpha,7alpha,12alpha-triol and microsomal 23R-, 24R-, 24S-, and 27-hydroxylations of 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol are mainly catalyzed by CYP3A in both mice and humans [1].
- The hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol by the rat liver microsomal fraction fortified with NADPH was stimulated about two-fold by administration of phenobarbital [2].
- Cholic acid biosynthesis: conversion of 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol into 5beta-cholestane-3alpha,7alpha, 12alpha,24beta,25-pentol by human and rat liver microsomes [2].
- This paper describes the conversion of 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol into 5beta-cholestane-3alpha,7alpha,12alpha,24beta,25-pentol by liver microsomes [2].
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