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Chemical Compound Review

OXDRALAZINE     2-[(6-hydrazinylpyridazin-3- yl)-(2...

Synonyms: di-HCl, AG-K-85639, AC1Q3APA, CTK4F9729, AR-1D0910, ...
This record was replaced with 28434.
 
 
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Disease relevance of L 6150

 

High impact information on L 6150

  • The triple regimen reduced blood pressure 35/15 mm Hg after one month (daily doses 25 mg chlorthalidone, 20 mg oxdralazine, 40 mg propranolol), and further increase in dosages caused a reduction of 45/24 mm Hg at the third month (daily doses 25 mg chlorthalidone, 56 +/- 20 mg oxdralazine, 112 +/- 40 mg propranolol) [2].
  • This combination seems particularly successful since propranolol will prevent the undesired rise in cardiac output due to oxdralazine as well as the activation of the renin-angiotensin axis due to diuretics [3].
  • Blood pressure did not return to normal limits in 15 patients, who were continued on the same protocol plus 10 to 50 mg oxdralazine q.d. After an average of 68 +/- 35 days blood pressure fell from 180/110 mm Hg to 145/90 mm Hg without orthostatism, significant side effects, or changes in GFR [3].
  • Effect of 3-hydrazino-6[N, N-bis (2-hydroxyethyl) amino]-pyridazine (L 6150) on renin in hypertensive rats [4].
 

Chemical compound and disease context of L 6150

 

Associations of L 6150 with other chemical compounds

References

  1. Hemodynamic effects of oxdralazine and hydralazine in hypertension. Moskowitz, R.M., Cohn, J.N. Clin. Pharmacol. Ther. (1980) [Pubmed]
  2. A crossover trial of oxdralazine in hypertension. Salvadeo, A., Villa, G., Segagni, S., Galli, F., Criscuolo, D. Journal of clinical pharmacology. (1983) [Pubmed]
  3. Oxdralazine, a new peripheral vasodilator, combined with propranolol and hydrochlorothiazide: a rational approach to antihypertensive treatment. Bartoli, E., Faedda, R., Arras, S., Satta, A., Soggia, G. Journal of clinical pharmacology. (1979) [Pubmed]
  4. Effect of 3-hydrazino-6[N, N-bis (2-hydroxyethyl) amino]-pyridazine (L 6150) on renin in hypertensive rats. Kawashima, K., Watanabe, T.X., Sokabe, H. Jpn. J. Pharmacol. (1980) [Pubmed]
  5. Comparative study of oxdralazine and dihydralazine in essential hypertension. Salvadeo, A., Villa, G., Segagni, S., Piazza, W., Criscuolo, D. International journal of clinical pharmacology, therapy, and toxicology. (1981) [Pubmed]
 
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