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Chemical Compound Review

CHEBI:15634     (2S)-2-[[4-[(2-amino-4-oxo- 7,8-dihydro-1H...

Synonyms: HMDB06485, AR-1J8790, AC1L52LA, AC1Q5QR7, C03204, ...
 
 
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Disease relevance of C03204

 

High impact information on C03204

  • It is likely that 10-formyldihydrofolate has been misidentified as 5,10-hydroxymethylenetetrahydrofolate, which was reported to accumulate during the hydrolysis of 5, 10-methenyltetrahydrofolate to 5-formyltetrahydrofolate [Stover, P. and Schirch, V. (1992) Biochemistry 31, 2148-2155 and 2155-2164; (1990) J. Biol. Chem. 265, 14227-14233] [3].
  • It had been the dogma that only tetrahydrofolates participate in enzyme-catalyzed one-carbon transfer reactions, until we showed in 1986 that 10-formyldihydrofolate serves as a substrate for aminoimidazolecarboxamide ribotide (AICAR) transformylase [4].

References

 
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