Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-K-70631 2-amino-2-hydrazinyl-3-(3H- imidazol-4...

Synonyms: CTK4H0398, AR-1D8171, AC1L53V9, AC1Q3E76, 33334-54-2, ...

This record was replaced with 169500.

Hollis, T.M. et al., Hollis, T.M. et al., Maśliński, C. et al., Carroll, W.J. et al.

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High impact information on 2-amino-2-hydrazinyl-3-(3H-imidazol-4-yl)propanoic acid

We also examined effects of insulin and alpha-hydrazinohistidine (alpha HH) treatments on retinal histamine synthesis in this diabetic model. alpha HH is a specific inhibitor of histidine decarboxylase [1].
The effects of tritoqualine and alpha-hydrazinohistidine injected into eggs on the 16th, 17th or 18th day of chick embryo age on hatching time, histamine level and diamine oxidase (DAO) activity in brood's tissues were also examined [2].

Anatomical context of 2-amino-2-hydrazinyl-3-(3H-imidazol-4-yl)propanoic acid

We studied rat aortic endothelial and smooth muscle cell de novo histamine synthesis mediated by histidine decarboxylase (HD) and the effects of its inhibition by alpha-hydrazinohistidine on the intracellular histamine content and intraaortic albumin accumulation in streptozotocin-induced diabetes [3].

Analytical, diagnostic and therapeutic context of 2-amino-2-hydrazinyl-3-(3H-imidazol-4-yl)propanoic acid

The aortic albumin mass transfer and flux rates of the diabetic group were more than 300% higher than that of the control group; alpha-hydrazinohistidine treated diabetic rats had aortic albumin mass transfer rates equivalent to control values [4].

References

Retinal histamine synthesis is increased in experimental diabetes. Carroll, W.J., Hollis, T.M., Gardner, T.W. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
Tritoqualine and some aspects of histamine metabolism. Maśliński, C., Fogel, W.A., Wyczółkowska, J., Nowak, J.Z. Arzneimittel-Forschung. (1986) [Pubmed]
Aortic endothelial and smooth muscle histamine metabolism. Relationship to aortic 125I-albumin accumulation in experimental diabetes. Hollis, T.M., Gallik, S.G., Orlidge, A., Yost, J.C. Arteriosclerosis (1983) [Pubmed]
Inhibition of aortic histamine synthesis by alpha-hydrazinohistidine inhibits increased aortic albumin accumulation in experimental diabetes in the rat. Hollis, T.M., Strickberger, S.A. Diabetologia (1985) [Pubmed]

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