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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Gly-sar-sar     (2S)-4-amino-2-(methyl-(2...

Synonyms: AC1L57UD, Glycylsarcosylsarcosine, Glycyl-sarcosyl-sarcosine
 
 
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High impact information on Glycylsarcosylsarcosine

  • We have investigated the relative contribution of hydrolysis, intact transport and urinary excretion to the renal clearance of Gly-Sar, Gly-Sar-Sar, and Gly-Gly-Sar in fed and starved rats [1].
  • 1. This paper describes the results of a survey of the effects of peptides and amino acids on uptake by rings of everted hamster jejunum in vitro of glycylsarcosylsarcosine, a tripeptide which is taken up by an active mechanism but is very resistant to hydrolysis, appearing intact in the rings [2].
  • Reasons are given for supposing that uptake of this peptide may be the result of Na+-dependent active transport by the same carrier as that utilized by glycylsarcosylsarcosine [3].
  • 3. The results add to information about the influence of molecular structure on intestinal uptake of peptides by the system used by glycylsarcosylsarcosine, which is shared by a wide range of other di- and tri-peptides [2].

References

  1. Oligopeptides: mechanism of renal clearance depends on molecular structure. Minami, H., Daniel, H., Morse, E.L., Adibi, S.A. Am. J. Physiol. (1992) [Pubmed]
  2. A common mechanism for transport of di- and tri-peptides by hamster jejunum in vitro. Addison, J.M., Burston, D., Dalrymple, J.A., Matthews, D.M., Payne, J.W., Sleisenger, M.H., Wilkinson, S. Clinical science and molecular medicine. (1975) [Pubmed]
  3. Evidence for active transport of tripeptides by hamster jejunum in vitro. Addison, J.M., Burston, D., Payne, J.W., Wilkinson, S., Matthews, D.M. Clinical science and molecular medicine. (1975) [Pubmed]
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