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Chemical Compound Review

SureCN462517     1-[(2-bromo-4,5-dimethoxy- phenyl)methyl]-6...

Synonyms: AG-G-09182, Oprea1_293762, AC1L5ACF, CTK1H3031, A-66359, ...
 
 
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Psychiatry related information on A 69024

  • Behavioral studies demonstrate that A-69024 HBr (5 mg/kg s.c.) is able to block both amphetamine-induced locomotor activity and apomorphine-induced stereotypy [1].
 

High impact information on A 69024

  • This was accomplished by examining the behavioral responses induced by SKF-38393, quinpirole, and L-DOPA after treatment with the D1 antagonist SCH-23390 and three new pharmacologic agents, SCH-39166, NO-0756, and A-69024, reported to be D1 antagonists [2].
  • Each of the new, putative selective D-1 antagonists SCH 39166, NO 756 and A-69024 antagonised typical behavioural responses to the selective D-2 agonist RU 24213 and concurrently released atypical behaviour [3].
  • The effects of chronic treatment (18 days) with the novel D1 antagonists, the benzonaphthazepine SCH 39166 (2 mg/kg per day) and the tetrahydroisoquinoline A-69024 (10 mg/kg per day), on D1 and D2 receptor binding in the rat brain were studied by quantitative receptor autoradiography [4].
  • Furthermore, A-69024 HBr blocks SF&F 38393-, but not quinpirole-, induced rotation in rats having unilateral 6-hydroxydopamine lesions of the substantia nigra [1].

References

  1. A-69024: a non-benzazepine antagonist with selectivity for the dopamine D-1 receptor. Kerkman, D.J., Ackerman, M., Artman, L.D., MacKenzie, R.G., Johnson, M.C., Bednarz, L., Montana, W., Asin, K.E., Stampfli, H., Kebabian, J.W. Eur. J. Pharmacol. (1989) [Pubmed]
  2. Pharmacologic evaluation of SCH-39166, A-69024, NO-0756, and SCH-23390 in neonatal-6-OHDA-lesioned rats. Further evidence that self-mutilatory behavior induced by L-dopa is related to D1 dopamine receptors. Criswell, H.E., Mueller, R.A., Breese, G.R. Neuropsychopharmacology (1992) [Pubmed]
  3. New classes of selective D-1 dopamine receptor antagonist provide further evidence for two directions of D-1:D-2 interaction. Daly, S.A., Waddington, J.L. Neurochem. Int. (1992) [Pubmed]
  4. Regulation of dopamine D1 receptors by chronic administration of structurally different D1 receptor antagonists: a quantitative autoradiographic study. Lappalainen, J., Hietala, J., Pohjalainen, T., Syvälahti, E. Eur. J. Pharmacol. (1992) [Pubmed]
 
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