Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-G-41881 (2S)-2-(hydroxyamino)-3-(4...

Synonyms: CHEBI:28089, AC1L5ASN, CTK1I6407, C03004, 63577-99-1, ...

Halkier, B.A. et al., Møller, B.L. et al., Sibbesen, O. et al.

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High impact information on N-Hydroxytyrosine

Earlier studies with microsomes have demonstrated that this conversion involves two N-hydroxylation reactions of which the first produces N-hydroxytyrosine [1].
Two oxygen molecules are consumed in the conversion of tyrosine to (E)-p-hydroxyphenylacetaldehyde oxime, indicating the existence of a previously undetected hydroxylation step in addition to that resulting in the formation of N-hydroxytyrosine [2].
The biosynthesis of cyanogenic glucosides in higher plants. N-Hydroxytyrosine as an intermediate in the biosynthesis of dhurrin by Sorghum bicolor (Linn) Moench [3].

References

Cytochrome P-450TYR is a multifunctional heme-thiolate enzyme catalyzing the conversion of L-tyrosine to p-hydroxyphenylacetaldehyde oxime in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. Sibbesen, O., Koch, B., Halkier, B.A., Møller, B.L. J. Biol. Chem. (1995) [Pubmed]
The biosynthesis of cyanogenic glucosides in higher plants. Identification of three hydroxylation steps in the biosynthesis of dhurrin in Sorghum bicolor (L.) Moench and the involvement of 1-ACI-nitro-2-(p-hydroxyphenyl)ethane as an intermediate. Halkier, B.A., Møller, B.L. J. Biol. Chem. (1990) [Pubmed]
The biosynthesis of cyanogenic glucosides in higher plants. N-Hydroxytyrosine as an intermediate in the biosynthesis of dhurrin by Sorghum bicolor (Linn) Moench. Møller, B.L., Conn, E.E. J. Biol. Chem. (1979) [Pubmed]

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