Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

ETI; icosa-5,8,11-triynoic acid

Synonyms: AG-K-14061, BSPBio_001451, KBioGR_000171, KBioSS_000171, CHEBI:53454, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on KBio2_002739

Additionally, the specific substrate analog lipoxygenase inhibitor, 5,8,11-eicosatriynoic acid, and the cyclooxygenase inhibitor, ibuprofen, were nonpotentiating [1].
The potential impact of GPR40 mutations on [(3)H]-myo-inositol turnover was estimated in COS-7 cells after stimulation with various concentrations of 5,8,11-eicosatriynoic acid [2].
Inhibition of lipoxygenase (LO) with 2.5 micromol/L of 5,8,11 eicosatriynoic acid (ETI), cyclooxygenase (CO) with 2 micromol/L of ibuprofen (IBU), and cytochrome P-450 (P450) with 1 micromol/L of 7-ethoxyresorufin (7ER) all reduced total Ang II-induced intracellular calcium transients ([Ca2+]i) in fura 2-loaded cultured rat VSMC [3].
The 12 week old SHR were given a bolus of the LO inhibitor 5,8,11-eicosatriynoic acid (ETI, 7 mg/kg, intravenously) and blood pressure measured after 20 min [4].
These results suggest that 30 microM 5,8,11-eicosatriynoic acid released Ca2+ from the endoplasmic reticulum, mitochondria and other stores [5].

Anatomical context of KBio2_002739

Synergistic enhancement of mitogen responses of human lymphocytes by inhibitors of cyclo-oxygenase and 5,8,11-eicosatriynoic acid, an inhibitor of 12-lipoxygenase and leukotriene biosynthesis [6].
5,8,11-eicosatriynoic acid (ETrYA) is a powerful inactivator only for reticulocyte lipoxygenase [7].

References

Flavonoid potentiation of contractile responses in rat blood vessels. Berger, M.E., Golub, M.S., Chang, C.T., al-Kharouf, J.A., Nyby, M.D., Hori, M., Brickman, A.S., Tuck, M.L. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release. Hamid, Y.H., Vissing, H., Holst, B., Urhammer, S.A., Pyke, C., Hansen, S.K., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Schwartz, T.W., Pedersen, O., Hansen, T. Diabet. Med. (2005) [Pubmed]
Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. Kanda, H., Hori, M.T., Golub, M.S., Tuck, M.L. Am. J. Hypertens. (2001) [Pubmed]
Elevated 12-lipoxygenase activity in the spontaneously hypertensive rat. Sasaki, M., Hori, M.T., Hino, T., Golub, M.S., Tuck, M.L. Am. J. Hypertens. (1997) [Pubmed]
Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase inhibitor, on Ca2+ mobilization in Madin Darby canine kidney cells. Lee, K.C., Chou, K.J., Cheng, J.S., Wang, J.L., Tang, K.Y., Tseng, L.L., Jan, C.R. Pharmacol. Toxicol. (2001) [Pubmed]
Synergistic enhancement of mitogen responses of human lymphocytes by inhibitors of cyclo-oxygenase and 5,8,11-eicosatriynoic acid, an inhibitor of 12-lipoxygenase and leukotriene biosynthesis. Blomgren, H., Hammarström, S., Wasserman, J. Int. Arch. Allergy Appl. Immunol. (1987) [Pubmed]
The inactivation of lipoxygenases by acetylenic fatty acids. Kühn, H., Schewe, T., Rapoport, S.M. Biomed. Biochim. Acta (1984) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share