Disease relevance of Clopidol

• Lerbek, a synergistic mixture of methyl benzoquate and clopidol for the prevention of chicken coccidiosis [1].
• Poults fed Clopidol (0.0125%) during the exposure period and subsequent experimental periods showed very little parasitemia and no significant reduction in arterial PO2 [2].
• In one experiment where chickens were infected with a strain resistant to amprolium plus ethopabate and clopidol, birds on dietary thiopeptin attained higher body weight than birds on the basal ration [3].
• In comparison with unmedicated rabbits, weight gain of metichlorpindol medicated rabbits was 4.76% lower after seven seeks of treatment, whereas feed conversion was improved by 1.87% [4].

High impact information on Clopidol

• Resistance of the chicken coccidium Eimeria tenella to the anticoccidial agents decoquinate and clopidol, and the synergistic activity of mixtures of these compounds have been confirmed in vivo [5].
• There is a correlation between the resistance of electron transport to inhibition by decoquinate or clopidol and the susceptibility to inhibition by cyanide or azide [5].
• Resistance to decoquinate and clopidol is discussed in view of a possibly branched electron transport chain in mitochondria of E. tenella [5].
• Model ecosystem evaluation of the environmental impacts of the veterinary drugs phenothiazine, sulfamethazine, clopidol, and diethylstilbestrol [6].
• Determination of nicarbazin and clopidol in poultry feeds by liquid chromatography [7].

Biological context of Clopidol

• The activity of methyl benzoquate and clopidol against Eimeria maxima: synergy and drug resistance [8].
• The virulence of a field strain of the chicken coccidian parasite Eimeria acervulina (Boreham I), dually resistant to the chemically unrelated anticoccidial agents decoquinate and clopidol, was compared with that of a drug-sensitive laboratory strain (Ongar) of the same species [9].
• Drugs that act early in the life cycle of coccidia (robenidine, clopidol, decoquinate, diclazuril, halofuginone, monensin, salinomycin, and lasalocid) were active at 5-125 micrograms/embryo when they were injected on the day of infection [10].
• Drug residues in the organs of broiler chickens after flock treatment with Rigecoccin R (clopidol) [11].

Anatomical context of Clopidol

• Resistance to amprolium and clopidol developed more readily in experiments where a large number of coccidia were exposed to the drug, either by increasing the number of oocysts in the inoculum or by increasing the number of birds in the group [12].

Associations of Clopidol with other chemical compounds

• Isobolograms showed that decoquinate and clopidol in fact potentiated each other's effect on electron transport [5].
• Methyl benzoquate at 20 ppm or clopidol at 250 ppm in the diet show true coccidiostatic activity in infections with Eimeria tenella in the chick [1].
• Eimeria tenella: experimental studies on the development of resistance to amprolium, clopidol and methyl benzoquate [12].
• The clopidol was separated on a column (30 cm x 3.9 mm) of microBondapak C18 (10 microm) by using acetonitrile-water (20 + 80, v/v) as mobile phase, and determined quantitatively at 270 nm [13].
• For 15 months the anticoccidial effect of 200 ppm clopidol/methyl benzoquate and of 50 ppm robenidine, and the development of immunity against five different species of Eimeria were followed in a closed rabbit population [14].

Analytical, diagnostic and therapeutic context of Clopidol

• They were killed 0-10 days after withdrawal of the premedicated feed and clopidol was determined in liver and muscle samples by a sensitive gas-liquid chromatography (g.l.c.) method [15].
• Metabolic fate of clopidol after repeated oral administration to rabbits [16].
• An automated HPLC determination of meticlorpindol in eggs with UV absorbance detection, using on-line dialysis and pre-concentration as sample clean-up; occurrence in and carry over to eggs [17].

References