Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-K-53394 2-(3-hydroxy-3,7,11,15- tetramethyl...

Synonyms: KST-1B0352, AC1L4NRX, CTK4B0568, AR-1B7916, AC1Q6B3L, ...

Trivedi, L.S. et al., Fasco, M.J. et al.

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Psychiatry related information on Hydroxyvitamin K

Alterations in the formation of hydroxyvitamin K occur in parallel with alterations in total vitamin K epoxide conversion with respect to reaction time, extent of reaction, detergent stimulation, and inhibition by warfarin [1].

High impact information on Hydroxyvitamin K

These data suggest that in resistant, but not in normal rat hepatocytes, the vitamin K 2,3-epoxide reductase makes a significant contribution to hydroxyvitamin K formation [2].

Associations of Hydroxyvitamin K with other chemical compounds

Vitamin K and 3- (and/or 2)-hydroxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone (hydroxyvitamin K) have been identified as metabolites of vitamin K 2,3-epoxide incubated with hepatocytes isolated from normal and warfarin-resistant rats [2].

References

Formation of hydroxyvitamin K by vitamin K epoxide reductase of warfarin-resistant rats. Fasco, M.J., Preusch, P.C., Hildebrandt, E., Suttie, J.W. J. Biol. Chem. (1983) [Pubmed]
Normal and warfarin-resistant rat hepatocyte metabolism of vitamin K 2,3-epoxide: evidence for multiple pathways of hydroxyvitamin K formation. Trivedi, L.S., Rhee, M., Galivan, J.H., Fasco, M.J. Arch. Biochem. Biophys. (1988) [Pubmed]

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