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Chemical Compound Review

GAGGL     (2R,3R,4R,5R)-4- [(2R,3R,4S,5R,6R)-3,5...

Synonyms: HMDB06599, AR-1F3304, AC1L4O1B, AC1Q6A7G, 32694-82-9, ...
 
 
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High impact information on Gal(beta1-3)-gal(beta1-4)glc

  • Unique to elephant milk are the high levels of 3'-galactosyllactose (up to 4 g/l) and lacto-N-neo-tetraose which are present in human milk only in trace amounts [1].
  • B-pentasaccharide was a dominant saccharide in early lactation milk, while alpha 3'-galactosyllactose was dominant in milk, later [2].
  • The chemical structure of the three trisaccharides were determined by methylation and 13C-NMR analyses to be as follows: Gal alpha 1-3Gal beta 1-4Glc, Gal beta 1-3Gal beta 1-4Glc (3'-galactosyllactose) and Gal beta 1-6Gal beta 1-4Glc (6'-galactosyllactose) [3].
 

Anatomical context of Gal(beta1-3)-gal(beta1-4)glc

  • Separation of human milk oligosaccharides by recycling chromatography. First isolation of lacto-N-neo-difucohexaose II and 3'-Galactosyllactose from this source [4].

References

  1. Lactose-derived oligosaccharides in the milk of elephants: comparison with human milk. Kunz, C., Rudloff, S., Schad, W., Braun, D. Br. J. Nutr. (1999) [Pubmed]
  2. Chemical characterization of milk oligosaccharides of the Japanese black bear, Ursus thibetanus japonicus. Urashima, T., Sumiyoshi, W., Nakamura, T., Arai, I., Saito, T., Komatsu, T., Tsubota, T. Biochim. Biophys. Acta (1999) [Pubmed]
  3. New galactosyllactose containing alpha-glycosidic linkage isolated from ovine (Booroola dorset) colostrum. Urashima, T., Saito, T., Nishimura, J., Ariga, H. Biochim. Biophys. Acta (1989) [Pubmed]
  4. Separation of human milk oligosaccharides by recycling chromatography. First isolation of lacto-N-neo-difucohexaose II and 3'-Galactosyllactose from this source. Donald, A.S., Feeney, J. Carbohydr. Res. (1988) [Pubmed]
 
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