Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-K-77409 (2R,3S)-2-amino-3-[(2S)-2- amino-2-carboxy...

Synonyms: KST-1A5680, CTK4I6682, AR-1A3457, AC1L4RV8, AC1Q5QN7, ...

Banerjee, S. et al., Ross, K.F. et al.

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Disease relevance of beta-Methyllanthionine

The precursor contains serines, threonines, and cysteines at positions that permit them to undergo a series of dehydration and cross-linking steps to give the mature antibiotic peptide which contains the unusual amino acids lanthionine, beta-methyllanthionine, D-alanine, dehydroalanine, and dehydrobutyrine [1].

High impact information on beta-Methyllanthionine

Analysis of the nucleotide sequence of this fragment indicated that salivaricin A is synthesized as a 51-amino-acid prepeptide that is posttranslationally modified and cleaved to give a biologically active 22-residue peptide containing one lanthionine and two beta-methyllanthionine residues [2].

References

Structure and expression of a gene encoding the precursor of subtilin, a small protein antibiotic. Banerjee, S., Hansen, J.N. J. Biol. Chem. (1988) [Pubmed]
Isolation and characterization of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 20P3. Ross, K.F., Ronson, C.W., Tagg, J.R. Appl. Environ. Microbiol. (1993) [Pubmed]

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