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Chemical Compound Review:

Capnine 2-amino-3-hydroxy-15-methyl- hexadecane-1...

Synonyms: AGN-PC-008GE9, AG-J-89836, CTK2H8352, AC1L50SP, AC1Q1PD1, ...

Godchaux, W. et al., Abbanat, D.R. et al., Godchaux, W. et al.

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Disease relevance of Capnine

Though capnine accumulates as such in the cells of some Capnocytophaga spp., most organisms of the Cytophaga-like genera contain, instead, sulfonolipids that are less polar than capnine [1].
Gliding bacteria of the genus Cytophaga synthesize sulfonolipids (1,2) that contain capnine (1-deoxy-15-methylhexadecasphinganine-1-sulfonic acid) [2].

High impact information on Capnine

Another lipid appears to be an N-acylated version of capnine; after acid hydrolysis, its sulfur was recovered in a form chromatographically indistinguishable from that of capnine [3].
The results are consistent with a pathway in which capnine is formed by condensation of cysteate with a fatty acyl CoA [2].

References

Sulfonolipids of gliding bacteria. Structure of the N-acylaminosulfonates. Godchaux, W., Leadbetter, E.R. J. Biol. Chem. (1984) [Pubmed]
Biosynthesis of a sulfonolipid in gliding bacteria. Abbanat, D.R., Godchaux, W., Polychroniou, G., Leadbetter, E.R. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
Capnocytophaga spp. contain sulfonolipids that are novel in procaryotes. Godchaux, W., Leadbetter, E.R. J. Bacteriol. (1980) [Pubmed]

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