Disease relevance of DIPHENOXYLATE

• These results suggest that temporary or intermittent therapy with Lomotil and related drugs might benefit patients with chronic diarrhea and fecal incontinence [1].
• Letter: Lomotil and antibiotic colitis [2].
• Delayed cardiopulmonary arrest after Lomotil ingestion [3].
• Eight pediatric accidental overdoses of diphenoxylate-atropine (Lomotil) are reported, and 28 literature cases are reviewed [4].
• Children with severe dehydration treated with lomotil spent on the average much shorter period in hospital than those on kaolin, but the numbers were too small to allow for useful comparison [5].

High impact information on DIPHENOXYLATE

• Acute effect of diphenoxylate with atropine (Lomotil) in patients with chronic diarrhea and fecal incontinence [1].
• Lomotil had no effect on rectal or anal sphincter pressure or on continence for saline that had been infused into the rectum [1].
• The use of Lomotil and Metamucil has assisted in decreasing the frequency of defecation, and also in developing semisolid stools [6].
• The evaluation and application of a radioimmunoassay for the measurement of diphenoxylic acid, the major metabolite of diphenoxylate hydrochloride (Lomotil), in human plasma [7].
• The assay was used to measure plasma concentrations of diphenoxylic acid in 12 human volunteers for up to 24 hr after ingestion of Lomotil (10mg) tablets [7].

Biological context of DIPHENOXYLATE

• A multicentre trial was conducted to compare Lomotil and Imodium in the treatment of acute non-specific diarrhoea in general practice [8].

References