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Chemical Compound Review:

MIDA 2-(carboxymethyl-methyl- amino)ethanoic acid

Synonyms: PubChem4905, ACMC-1AS83, M51008_ALDRICH, AG-F-55185, ANW-30060, ...

Meinardus-Hager, G. et al., Cameron, B.R. et al., Sandee, B. et al., Fields, J.H. et al.

Cameron, Darkes, Baird, Skerlj, Santucci, Fricker,

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Disease relevance of Methyliminodiacetic acid

Despite the remarkably high activities of the enzymes alanopine and strombine dehydrogenase only negligible amounts of alanopine are found after anoxia and no production of strombine occurs [1].

High impact information on Methyliminodiacetic acid

A series of [Ru(III)(tacn)(pyc)Cl][PF(6)] (pyc = 2-pyridinecarboxylic acid, 2,4- and 2,6-pyridinecarboxylic acid) complexes, 14-16, were prepared along with [Ru(III)(tacn)(mida)][PF(6)] (mida = N-methyliminodiacetic acid), 13, and [Ru(III)(Hnota)Cl], 17, (Hnota = 1-acetic acid-4,7-bismethylcarboxylate-1,4,7-triazacyclononane) [2].
Alanopine and strombine are novel imino acids produced by a dehydrogenase found in the adductor muscle of the oyster, Crassostrea gigas [3].
Three enzymes with pyruvate reductase activity (lactate-, octopine-, alanopine/strombine dehydrogenase) can possibly serve as the terminal step of anaerobic glycolysis [1].

Analytical, diagnostic and therapeutic context of Methyliminodiacetic acid

A sensitive HPLC method is presented for the determination of the imino acids alanopine and strombine, anaerobic metabolites that are formed in muscle tissue of several species of invertebrates [4].

References

The pyruvate branchpoint in the anaerobic energy metabolism of the jumping cockle Cardium tuberculatum L.: D-lactate formation during environmental anaerobiosis versus octopine formation during exercise. Meinardus-Hager, G., Gäde, G. Experimental biology. (1986) [Pubmed]
Ruthenium(III) triazacyclononane dithiocarbamate, pyridinecarboxylate, or aminocarboxylate complexes as scavengers of nitric oxide. Cameron, B.R., Darkes, M.C., Baird, I.R., Skerlj, R.T., Santucci, Z.L., Fricker, S.P. Inorganic chemistry. (2003) [Pubmed]
Alanopine and strombine are novel imino acids produced by a dehydrogenase found in the adductor muscle of the oyster, Crassostrea gigas. Fields, J.H., Eng, A.K., Ramsden, W.D., Hochachka, P.W., Weinstein, B. Arch. Biochem. Biophys. (1980) [Pubmed]
High-performance liquid chromatographic determination of the imino acids (opines) meso-alanopine and D-strombine in muscle extract of invertebrates. Sandee, B., Schipper, C.A., Eertman, R.H. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]

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