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Chemical Compound Review:

CHEMBL567422 1-[6-(2,5-dioxopyrrol-1- yl)hexyl]pyrrole-2...

Synonyms: SureCN141227, ACMC-209kdc, ANW-30670, CCG-19056, NSC-12818, ...

Chen, J.J. et al., Chen, Z. et al., Kwon, Y.K. et al., Ferreira, P. et al., Yang, J.M. et al.

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High impact information on NSC12818

A thiol-reactive membrane-associated protein (TRAP) binds covalently to the cytoplasmic domain of the human insulin receptor (IR) beta-subunit when cells are treated with the homobifunctional cross-linker reagent 1,6-bismaleimidohexane [1].
Although L31C-PLB failed to cross-link to any Cys or Lys residue of wild-type SERCA2a, L31C did cross-link with high efficiency to T317C of SERCA2a with use of the homobifunctional sulfhydryl cross-linking reagent, 1,6-bismaleimidohexane [2].
HRI in the reticulocyte lysate can be cross-linked by 1,6-bismaleimidohexane (bis-NEM) [3].
A similar high molecular mass form is observed when HRI is treated with 1,6-bismaleimidohexane, a double sulfhydryl cross-linker agent, and the autophosphorylation of HRI and the phosphorylation of eIF-2 alpha by HRI are greatly diminished; these effects are similar to the effects of hemin on HRI [4].
Iloprost-induced desensitization was accompanied by the formation of a Gsalpha-containing 90-kDa product in membranes treated with the bifunctional cross-linker 1,6-bismaleimidohexane [5].

References

Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor. Kwon, Y.K., Jang, H.J., Kole, S., He, H.J., Bernier, M. J. Cell Biol. (2003) [Pubmed]
Role of leucine 31 of phospholamban in structural and functional interactions with the Ca2+ pump of cardiac sarcoplasmic reticulum. Chen, Z., Stokes, D.L., Jones, L.R. J. Biol. Chem. (2005) [Pubmed]
Effects of hemin and porphyrin compounds on intersubunit disulfide formation of heme-regulated eIF-2 alpha kinase and the regulation of protein synthesis in reticulocyte lysates. Yang, J.M., London, I.M., Chen, J.J. J. Biol. Chem. (1992) [Pubmed]
Disulfide bond formation in the regulation of eIF-2 alpha kinase by heme. Chen, J.J., Yang, J.M., Petryshyn, R., Kosower, N., London, I.M. J. Biol. Chem. (1989) [Pubmed]
Selective formation of Gsalpha-MHC I complexes after desensitization of human platelets with iloprost. Ferreira, P., Meyer, I., Mollner, S., Frank, R., Pfeuffer, T. Eur. J. Biochem. (1999) [Pubmed]

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