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Chemical Compound Review

Mexitil     1-(2,6- dimethylphenoxy)propan-2- amine...

Synonyms: Ritalmex, mexilitene, Katen, Mexiletine HCL, Prestwick_666, ...
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Disease relevance of Mexiletine

 

High impact information on Mexiletine

  • Fourteen healthy volunteers, 10 with the extensive metabolizer (EM) and 4 with the poor metabolizer (PM) phenotype, received a single 200-mg dose of mexiletine hydrochloride orally on two occasions (1 week apart), once alone and once under steady-state conditions for quinidine (50 mg QID) [6].
  • The effect of advancing age on the kinetics of the antiarrhythmic agent mexiletine was studied by comparing various kinetic parameters calculated after administration of a single oral dose of mexiletine hydrochloride to seven elderly and eight young healthy volunteers [7].
  • The pharmacokinetics of S-(+)- and R-(-)-mexiletine and of the corresponding conjugates were investigated in six healthy young volunteers after administration of a single 200 mg oral dose of racemic mexiletine hydrochloride [8].
  • Attenuating effect of mexiletine hydrochloride on herpetic pain in mice infected with herpes simplex virus [9].
  • The assay was shown to be suitable for a pharmacokinetic study performed in a patient with the arrhythmic form of chronic Chagas' heart disease treated with 200 mg t.i.d. of racemic mexiletine hydrochloride [10].
 

Chemical compound and disease context of Mexiletine

 

Biological context of Mexiletine

 

Anatomical context of Mexiletine

 

Gene context of Mexiletine

 

Analytical, diagnostic and therapeutic context of Mexiletine

References

  1. Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. Kanai, K., Kuwabara, S., Arai, K., Sung, J.Y., Ogawara, K., Hattori, T. Brain (2003) [Pubmed]
  2. Mexiletine. Long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias. Kerin, N.Z., Aragon, E., Marinescu, G., Faitel, K., Frumin, H., Rubenfire, M. Arch. Intern. Med. (1990) [Pubmed]
  3. Contact urticaria induced by mexiletine hydrochloride in a patient receiving iontophoresis. Yamazaki, S., Katayama, I., Kurumaji, Y., Yokozeki, H., Nishioka, K. Br. J. Dermatol. (1994) [Pubmed]
  4. Generalized drug eruption due to mexiletine hydrochloride: topical provocation on previously involved skin. Kikuchi, K., Tsunoda, T., Tagami, H. Contact Derm. (1991) [Pubmed]
  5. Long QTc and torsades de pointes in human immunodeficiency virus disease. Kocheril, A.G., Bokhari, S.A., Batsford, W.P., Sinusas, A.J. Pacing and clinical electrophysiology : PACE. (1997) [Pubmed]
  6. Influence of debrisoquine phenotype and of quinidine on mexiletine disposition in man. Turgeon, J., Fiset, C., Giguère, R., Gilbert, M., Moerike, K., Rouleau, J.R., Kroemer, H.K., Eichelbaum, M., Grech-Bélanger, O., Bélanger, P.M. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  7. Pharmacokinetics of mexiletine in the elderly. Grech-Bélanger, O., Barbeau, G., Kishka, P., Fiset, C., LeBoeuf, E., Blouin, M. Journal of clinical pharmacology. (1989) [Pubmed]
  8. Stereoselective disposition of mexiletine in man. Grech-Belanger, O., Turgeon, J., Gilbert, M. British journal of clinical pharmacology. (1986) [Pubmed]
  9. Attenuating effect of mexiletine hydrochloride on herpetic pain in mice infected with herpes simplex virus. Asano, K., Sameshima, T., Shirasawa, H., Hisamitsu, T. J. Pharm. Pharmacol. (2003) [Pubmed]
  10. Enantioselective analysis of N-hydroxymexiletine glucuronide in human plasma for pharmacokinetic studies. Lanchote, V.L., Santos, V.J., Cesarino, E.J., Dreossi, S.A., Mere Júnior, Y., Santos, S.R. Chirality. (1999) [Pubmed]
  11. Gas chromatography-electron ionization and chemical ionization mass spectrometric analysis of serum mexiletine concentration after derivatization with 2,2,2-trichloroethyl chloroformate: a novel derivative. Dasgupta, A., Appenzeller, P., Moore, J. Therapeutic drug monitoring. (1998) [Pubmed]
  12. Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias. Morganroth, J. Am. J. Cardiol. (1987) [Pubmed]
  13. A case of drug eruption due to simultaneous sensitization with three different kinds of drugs. Nagayama, H., Nakamura, Y., Shinkai, H. J. Dermatol. (1996) [Pubmed]
  14. The dissolution and oral bioavailability of mexiletine capsules modified for clinical trial. A preliminary report. Chan, K., Tse, J., Deeks, P.A., Pilling, M. Methods and findings in experimental and clinical pharmacology. (1983) [Pubmed]
  15. Persistence of the electrophysiologic effects of mexiletine in canine Purkinje fibers alters the response to subsequent hypoxia. Berman, N.D., Ogilvie, R.I., Loukides, J.E. Can. J. Physiol. Pharmacol. (1987) [Pubmed]
  16. Mexiletine hydrochloride in an infant with intractable epilepsy. Kohyama, J., Shimohira, M., Watanabe, S., Fukuda, C., Iwakawa, Y. Brain Dev. (1988) [Pubmed]
  17. Effect of rifampicin treatment on the kinetics of mexiletine. Pentikäinen, P.J., Koivula, I.H., Hiltunen, H.A. Eur. J. Clin. Pharmacol. (1982) [Pubmed]
  18. Acute exanthematous pustular drug eruption induced by mexiletine. Sasaki, K., Yamamoto, T., Kishi, M., Yokozeki, H., Nishioka, K. European journal of dermatology : EJD. (2001) [Pubmed]
 
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