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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AG-K-52833     4-[7-(1-adamantyl)-6-(2...

Synonyms: SureCN1361023, CTK4D3563, CD2665, AR-1G0245, CD 2665, ...
 
 
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Psychiatry related information on CD2665

  • The administration of CD2665 to alcohol-treated mice totally reversed the working memory deficit and suppressed the overexpression of brain RARbeta, RXRbeta/gamma and tTG mRNA, whereas the same treatment in control mice decreased only the RARbeta mRNA level without affecting memory performance [1].
 

High impact information on CD2665

  • Accordingly, treatment of HiB5 cells with RARgamma-selective agonist (CD666) increased HiB5 cell number in a dose-dependent manner, which was blocked by co-treatment with RARgamma-selective antagonist (CD2665) [2].
  • The antagonist for RAR-beta/gamma CD2665 as well as the selective agonists for RAR-alpha CD336 and RAR-beta CD2019 were less effective in growth inhibition than ATRA [3].

References

  1. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alfos, S., Boucheron, C., Pallet, V., Higueret, D., Enderlin, V., Béracochéa, D., Jaffard, R., Higueret, P. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  2. Activation of retinoic acid receptor gamma induces proliferation of immortalized hippocampal progenitor cells. Chung, J.J., Cho, S., Kwon, Y.K., Kim, D.H., Kim, K. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  3. Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma. Meister, B., Fink, F.M., Hittmair, A., Marth, C., Widschwendter, M. Anticancer Res. (1998) [Pubmed]
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