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Chemical Compound Review:

NSC-1695 [3,4,5-triacetyloxy-6-[3,4- diacetyloxy-2,5...

Synonyms: NSC1695, KST-1B0553, AR-1B6146, FT-0631733, AC1L57QO, ...

Spielman, A.I. et al., Delwiche, J.F. et al., Kim, J. et al., Boughter, J.D. et al., Boughter, J.D. et al.

Boughter, Whitney,

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Psychiatry related information on NSC1695

By examining individual differences, ratings and rankings could be grouped into two general clusters--urea/phenylalanine/tryptophan/epicatechin, and quinine/caffeine/SOA/denatonium benzoate/tetralone/magnesium sulfate-none of which contained PROP [1].

High impact information on NSC1695

Micron-sized particles and thin films of sucrose octaacetate (SOA) were formed on silicon wafer substrate coupons from DISP at relatively low temperatures and pressures (< or = 6500 psi and < or = 60 degrees C) [2].
Soa allelic variation had a major effect on sensitivity to 0.003-1.0 mM SOA and several concentrations of the bitter-tasting alkaloids brucine, strychnine, and quinine [3].
Inbred strains are classified according to SOA phenotype as tasters, nontasters, or demitasters (intermediate sensitivity) [4].
The GTP-enhanced SOA-response supports a G protein-mediated response for this bitter compound [5].
Using a quench-flow system, we have studied bitter taste signal transduction in a pair of mouse strains that differ in their ability to taste the bitter stimulus sucrose octaacetate (SOA); however, both strains taste the bitter agent denatonium [5].

References

Covariation in individuals' sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms. Delwiche, J.F., Buletic, Z., Breslin, P.A. Perception & psychophysics. (2001) [Pubmed]
Deposition of small organic molecules by the displacement of two immiscible supercritical phases. Kim, J., Carbonell, R.G. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
Behavioral specificity of the bitter taste gene Soa. Boughter, J.D., Whitney, G. Physiol. Behav. (1997) [Pubmed]
C3.SW-Soaa heterozygous congenic taster mice. Boughter, J.D., Whitney, G. Behav. Genet. (1995) [Pubmed]
Rapid kinetics of second messenger production in bitter taste. Spielman, A.I., Nagai, H., Sunavala, G., Dasso, M., Breer, H., Boekhoff, I., Huque, T., Whitney, G., Brand, J.G. Am. J. Physiol. (1996) [Pubmed]

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