Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L2JQN (1R,4aR)-7-ethenyl-1,4a,7- trimethyl-3,4,4b...

Synonyms: 5835-26-7, 4-Epi-isopimaric acid

Cantillo-Ciau, Z. et al., Smith, E. et al., Wilson, A.E. et al.

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Disease relevance of ISOPIMARIC ACID

We isolated two aerobic, gram-negative bacteria which grew on the diterpene resin acid isopimaric acid (IpA) as the sole carbon source and electron donor [1].
Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus [2].

High impact information on ISOPIMARIC ACID

These results show that isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics [2].
The leaves of Tillandsia brachycaulos afforded two novel tetracyclic triterpenoids identified as (24S)-24-isopropenyl-29-nor-5alpha-lanosta-7-en-3beta-ol (1) and (24S)-24-isopropenyl-29-nor-5alpha-lanosta-7-en-3-one (2), in addition to the known isopimaric acid (3) and chlorogenic acid (4) [3].

References

Isolation and characterization of isopimaric acid-degrading bacteria from a sequencing batch reactor. Wilson, A.E., Moore, E.R., Mohn, W.W. Appl. Environ. Microbiol. (1996) [Pubmed]
Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus. Smith, E., Williamson, E., Zloh, M., Gibbons, S. Phytotherapy research : PTR. (2005) [Pubmed]
Two new 24-isopropenyl-lanostanoids from Tillandsia brachycaulos. Cantillo-Ciau, Z., Mena-Rejón, G.J., Quintero-Mármol, E., Jiménez-Díaz, A., Quijano, L. Z. Naturforsch., C, J. Biosci. (2003) [Pubmed]

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