Disease relevance of Androstenediol

• Effects of aminoglutethimide on delta 5-androstenediol metabolism in postmenopausal women with breast cancer [1].
• These results demonstrate the presence of 3beta-hydroxy steroid oxidoreductase, delta4- delta5 isomerase, 5alpha-reductase, and 17beta-ol dehydrogenase in the rat brain which may in part explain the behavioral and brain virilization effects of 5-androstenediol [2].
• Radioprotective efficacy and acute toxicity of 5-androstenediol after subcutaneous or oral administration in mice [3].

High impact information on Androstenediol

• Conversely, although 5-androstenediol was an excellent substrate for LCAT, only the 3beta-hydroxyl was esterified [4].
• We showed previously that 5-androstenediol stimulates myelopoiesis, increases the numbers of circulating neutrophils and platelets, and enhances resistance to infection in gamma-irradiated mice [5].
• In vivo radioprotection by 5-androstenediol: stimulation of the innate immune system [5].
• The development of inhibitors to block the formation of estrone and 5-androstenediol from sulfated precursors is an important new strategy for the treatment of breast cancer [6].
• Androstanediol and 5-androstenediol profiling for detecting exogenously administered dihydrotestosterone, epitestosterone, and dehydroepiandrosterone: potential use in gas chromatography isotope ratio mass spectrometry [7].

Biological context of Androstenediol

• In adult male Macaca fascicularis, spermatic vein (SV) concentrations of 5AD and 4A were comparable (3.0 +/- 1.2 vs 4.3 +/- 1.0 ng/ml) as well as SV/PV ratios under basal conditions (3.5 +/- 0.9 vs 5.1 +/- 0.1), as well as 48 h after hCG, confirming in vivo that both 5-ene and 4-ene pathways are involved in testicular T biogenesis [8].
• Additional binding sites for delta 5-androstenediol and estradiol in serum [9].
• Delta 5-androstenediol: kinetics of metabolism and binding to plasma proteins in normal post-menopausal women [10].
• 5-androstenediol stimulates multilineage hematopoiesis in rhesus monkeys with radiation-induced myelosuppression [11].
• Testosterone and 5-androstenediol increased the proportion of protein, but none of them had a significant effect on lipid deposition or heat production [12].

Anatomical context of Androstenediol

• In vitro conversion of 5-androstenediol to testosterone by the central nervous system and pituitary of the male rat [2].

Associations of Androstenediol with other chemical compounds

• Prepubertally castrated boars received subcutaneous injections twice weekly, from 12 to 38 weeks of age, of testosterone or 5-androstenediol (5-androstene-3 beta,17 beta-eiol) (2 mg/5 kg), or each of these steroids in combination with oestrone (1 mg/5 kg) [13].
• Since the steroid 5-androstene-3beta, 17beta-diol (5-androstenediol, AED) modulates cytokine expression and increases resistance to bacterial and viral infections in rodents, we tested its ability to promote survival after whole-body ionizing radiation in mice [14].
• In contrast, the oxidation of 5-androstenediol to DHA and the formation of highly polar metabolites is maximal at the end of the second and early in the third trimester and decreases as the delivery approaches [15].
• The evidence was based on the in vitro formation of [4-14C] testosterone and [4-14C] androstenedione from [4-14C] 5-androstenediol and [4-14CA1 DEHYDROEPIANDROSTERONE, RESPECTIVELY [16].

Gene context of Androstenediol

• Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF [17].

References