Disease relevance of 2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one

• Administration of 5% sodium erythorbate in the diet significantly increased the incidences of preneoplastic lesions, papilloma and cancer of the urinary bladder, whereas administration of 5% ascorbic acid in the diet did not [1].
• The thermal inactivation of Salmonella thompson, Escherichia coli, Staphylococcus aureus, Clostridium perfringens, Candida zeylanoides, Enterococcus faecium and E. faecalis was accelerated by the addition of sodium isoascorbate (1 mmol/l) to phosphate-buffer heating medium but not to complex food mixtures [2].

High impact information on 2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one

• Ascorbic acid was not transported by these myeloid cells, indicating that they do not express a sodium-ascorbate cotransporter [3].
• Assessing plant response to ambient ozone: growth of ozone-sensitive loblolly pine seedlings treated with ethylenediurea or sodium erythorbate [4].
• EGCG, GA and SA dose-dependently induced HSG cell death [5].
• Administrations of 5% sodium L-ascorbate and 5% sodium erythorbate caused increases in the pH, the sodium content and crystals of MgNH4PO4 in the urine [1].
• RESULTS: The Kruskal-Wallis followed by Mann-Whitney test showed that both sodium-hypochlorite and hydrogen-peroxide deteriorated the marginal seal of the dentin adhesive (P < 0.05), however, following both irrigation solutions the use of sodium-ascorbate reduced the microleakage (P < 0.05) [6].

Biological context of 2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one

• Sodium erythorbate (SE) was administered at concentrations of 0, 1.25, or 2.5% (maximum tolerated dose, MTD) in the drinking-water to groups of 50 male B6C3F1 mice respectively [7].

Associations of 2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one with other chemical compounds

• In experiment 1, the sequential administration of sodium saccharin (SS, 5.0%), DL-tryptophan (Tr, 2.0%) and sodium L-ascorbate (SA, 5.0%) in the diet, each for 10 weeks, significantly increased the incidence and the number of bladder tumors over that observed after SS alone or SS followed by Tr [8].

References