Disease relevance of Methetharimide

• Megimide-induced epileptic seizures were recorded in nine male El and six male ddY mice with the chronic implantation technique for monopolar recording of electrocorticogram (ECoG) [1].

Psychiatry related information on Methetharimide

• The analeptic drug, bemegride was found effective in antagonizing the P-barb. cued choice behavior [2].
• Brotizolam inhibited spontaneous motor activities; performances in the rotarod test, staircase test, and maximal electroshock seizure test; and pentetrazol- or bemegride-induced convulsion [3].

High impact information on Methetharimide

• Pentylenetetrazol (30 mg kg-1 i.v.) and bemegride (5 mg kg-1 i.v.) produced an increase in the blood flow and a corresponding increase in the cerebral oxygen consumption [4].
• Comparative study of the antagonism of bemegride and picrotoxin on behavioural depressant effects of diazepam in rats and mice [5].
• Bicuculline, picrotoxin, strychnine, leptazol, bemegride, and also theophylline and d-tubocurarine all increased the duration and amplitude of the excitatory postsynaptic potential, thereby producing a seizure-like discharge [6].
• Clinico-ECoG correlate of megimide-induced epileptic seizures in epilepsy-prone El and its mother strain nonepileptic ddY mice [1].
• Changes of brain images in single photon emission CTs (SPECTs) before and after intravenous injection of bemegride were examined with simultaneous EEG recording in a patient with occipital lobe epilepsy and in a hysteric patient, using a new method, i.e. subtraction of the SPECT images with 99mTc hexamethyl-propyleneamine oxime [7].

Biological context of Methetharimide

• Reversed-phase high-performance liquid chromatography method for the determination of bemegride in serum and brain tissue: pharmacokinetics and brain distribution of an intraperitoneal subconvulsive dose in rats [8].
• It is suggested that this hippocampal subsensitivity found in E1(+) mouse might be strain-specific, because repeated megimide convulsions failed to produce the same down regulation [9].

Anatomical context of Methetharimide

• Administration of subconvulsant doses of bemegride results in extensive enhancement of sensory responsiveness to auditory, visual, somatosensory and vibrissa stimulation of neurons in the medullary and mesencephalic reticular formation (RF) [10].
• Although a bemegride-induced seizure arose from the right side during the subdural recording, the onset of 5 habitual seizures was observed in the left hippocampus [11].
• It was evidenced that the model convulsive activity provoked by Bemegrid increased NEFA in the brain cortex, hypothalamus and brain stem [12].

Associations of Methetharimide with other chemical compounds

• The guinea-pig isolated atrium as a model system for the central actions of selected CNS stimulant and depressant drugs. Part 2. Mechanisms involved in the actions and interactions of the convulsant bemegride and its hypnotic homologue 3-methyl-3-n-butylglutarimide [13].
• Methaqualone discrimination in gerbils: interactions with bemegride and imidazoline (DH-524) [14].

Gene context of Methetharimide

• Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture [15].

Analytical, diagnostic and therapeutic context of Methetharimide

• A simple and rapid HPLC method has been developed for the quantification of bemegride in serum and brain tissue, using p-methylphenobarbital as an internal standard [8].
• Another patient, with informed consent, underwent a follow-up SPECT in combination with pharmacologic activation with bemegride [16].

References