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Chemical Compound Review

AG-G-85520     2-iodo-N-[2-(2- iodoethanoylamino)ethyl]eth...

Synonyms: CHEMBL1911792, NSC-30028, LS-9544, AC1L2MTV, NSC30028, ...
 
 
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High impact information on NSC30028

  • We have previously found (Ludueña, R. F., and Roach, M. C. (1981b) Biochemistry 20, 4444-4450) that colchicine and podophyllotoxin inhibit the alkylation of tubulin by iodo[14C]acetamide and the formation of an intrachain cross-link in the beta-tubulin subunit by N,N'-ethylenebis(iodoacetamide) (EBI) [1].
  • We now find that when the two tubulins, in their native states, are incubated with N,N'-ethylenebis(iodoacetamide) (EBI), a bifunctional sulfhydryl-directed reagent, microtubule assembly by brain tubulin is much more sensitive to inhibition by EBI than is erythrocyte tubulin assembly [2].
  • We have examined the effect of MPMAP on the alkylation of tubulin by iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide) (EBI) [3].
 

Anatomical context of NSC30028

References

 
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