Disease relevance of EINECS 231-656-8

• Such preventive activity is higher by far than that obtainable when lactobacillus or arginine aspartate are administered singly to the rats [1].

Psychiatry related information on EINECS 231-656-8

• In all 5 subjects the slow wave sleep related GH peak was about 60% higher after a week of arginine aspartate administration than in the control period, with individual changes of +24, +25, +42, +47 and +162% [2].

High impact information on EINECS 231-656-8

• The epitope recognized by mAb U1 70K was previously shown to be a repeating arginine/aspartate (RD) dipeptide [3].
• Slices from the left and right IMHV of trained and untrained chicks were superfused with Krebs' solution either with or without calcium and the superfusate assayed for arginine, aspartate, citrulline, GABA, glutamate, glycine and taurine using high-performance liquid chromatography [4].
• Measurement of amino acid uptake show that the mutants with high glutamine synthetase levels have increased rates for glutamine, arginine, aspartate, and lysine, but a decreased rate for proline [5].
• Thirty elderly, healthy, human volunteers (15 men and 15 women) received daily supplements of 30 gm arginine aspartate (17 gm free arginine) [6].
• The intake of arginine aspartate has been shown to increase anabolic hormones like human growth hormone (hGH) and glucagon [7].

Chemical compound and disease context of EINECS 231-656-8

• The cholesterol levels (expressed as mg x dL-1) are in fact: 45.5 for the control diet; 185.4 for the cholesterol-enriched diet; 131.1 for the cholesterol-enriched diet + lactobacillus; 178.2 for the cholesterol enriched diet + arginine aspartate and 122.4 for the cholesterol-enriched diet + lactobacillus + arginine aspartate [1].

Biological context of EINECS 231-656-8

• The NA active site is highly polar and formed mostly by arginine, aspartate and glutamate residues [8].

Gene context of EINECS 231-656-8

• Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man [2].
• The nocturnal mean plasma Prl of each subject was higher after arginine aspartate than before [2].
• Effects of arginine aspartate and its components on growth hormone, insulin and glucagon secretion in the rat [9].

Analytical, diagnostic and therapeutic context of EINECS 231-656-8

• To investigate the effect of the ingestion of arginine aspartate (AA) in the decrease of the exercise-induced accumulation of ammonia in plasma, 11 voluntary subjects took part in a cross-over study where AA effect was tested against placebo [10].

References