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Chemical Compound Review

Silicone oils     dimethyl- bis(trimethylsilyloxy)silane

Synonyms: Baysilon, Silastic, Dimeticona, Dimeticone, Polysilane, ...
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Disease relevance of Simethicone


High impact information on Simethicone


Chemical compound and disease context of Simethicone


Anatomical context of Simethicone


Associations of Simethicone with other chemical compounds

  • In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo [12].
  • We prospectively studied 26 patients receiving simethicone (n = 14) or placebo (n = 12) in Colyte (Edlaw Preparations. Inc., Farmingdale, NY, U.S.A.) to determine if the addition of simethicone could improve visibility when administered the night before colonoscopy [13].
  • H2 production from stool incubated with simethicone or placebo indicated that the drug had no effect in reducing the fermentative production of H2 in vitro [14].
  • Improved image quality during abdominal ultrasonography by clebopride + simethicone [15].
  • The bonding strength in the APTES treated devices was significantly greater than in devices fabricated using either a PDMS "glue" or two-part epoxy bonding method [16].
  • Contact angle measurements and ATR-FTIR analysis show that the surface chemistry of the NaOH treated PDMS differs from O2 plasma treated PDMS [17].

Analytical, diagnostic and therapeutic context of Simethicone


  1. Unique susceptibility of Helicobacter pylori to simethicone emulsifiers in alimentary therapeutic agents. Kane, A.V., Plaut, A.G. Antimicrob. Agents Chemother. (1996) [Pubmed]
  2. Simethicone in the treatment of infant colic: a randomized, placebo-controlled, multicenter trial. Metcalf, T.J., Irons, T.G., Sher, L.D., Young, P.C. Pediatrics (1994) [Pubmed]
  3. Randomised double-blind comparison of simethicone with cisapride in functional dyspepsia. Holtmann, G., Gschossmann, J., Karaus, M., Fischer, T., Becker, B., Mayr, P., Gerken, G. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  4. Efficacy and tolerability of polyethylene glycol-electrolyte lavage solution with and without simethicone in the preparation of patients with inflammatory bowel disease for colonoscopy. Lazzaroni, M., Petrillo, M., Desideri, S., Bianchi Porro, G. Aliment. Pharmacol. Ther. (1993) [Pubmed]
  5. Activated charcoal, simethicone, and intestinal gas: a double-blind study. Jain, N.K., Patel, V.P., Pitchumoni, S. Ann. Intern. Med. (1986) [Pubmed]
  6. The value of simethicone in abdominal preparation. Suoranta, H., Standertskjöld-Nordenstam, C.G., Lähde, S. Radiology. (1979) [Pubmed]
  7. A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia. Holtmann, G., Gschossmann, J., Mayr, P., Talley, N.J. Aliment. Pharmacol. Ther. (2002) [Pubmed]
  8. Simethicone for small bowel preparation for capsule endoscopy: a systematic, single-blinded, controlled study. Albert, J., Göbel, C.M., Lesske, J., Lotterer, E., Nietsch, H., Fleig, W.E. Gastrointest. Endosc. (2004) [Pubmed]
  9. Mylicon drops in the treatment of infant colic. Becker, N., Lombardi, P., Sidoti, E., Katkin, L.S. Clinical therapeutics. (1988) [Pubmed]
  10. Lactobacillus reuteri (American Type Culture Collection Strain 55730) Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized Study. Savino, F., Pelle, E., Palumeri, E., Oggero, R., Miniero, R. Pediatrics (2007) [Pubmed]
  11. Randomized placebo-controlled trial of oral liquid simethicone prior to upper gastrointestinal endoscopy. Bertoni, G., Gumina, C., Conigliaro, R., Ricci, E., Staffetti, J., Mortilla, M.G., Pacchione, D. Endoscopy. (1992) [Pubmed]
  12. Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms. Friis, H., Bodé, S., Rumessen, J.J., Gudmand-Høyer, E. Digestion (1991) [Pubmed]
  13. The effect of simethicone on colonic visibility after night-prior colonic lavage. A double-blind randomized study. McNally, P.R., Maydonovitch, C.L., Wong, R.K. J. Clin. Gastroenterol. (1989) [Pubmed]
  14. Effect of a simethicone-containing tablet on colonic gas elimination in breath. Lifschitz, C.H., Irving, C.S., Smith, E.O. Dig. Dis. Sci. (1985) [Pubmed]
  15. Improved image quality during abdominal ultrasonography by clebopride + simethicone. Varas, M.J., López, A. Methods and findings in experimental and clinical pharmacology. (1991) [Pubmed]
  16. Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices. Aran, K., Sasso, L.A., Kamdar, N., Zahn, J.D. Lab. Chip (2010) [Pubmed]
  17. Sodium hydroxide treatment of PDMS based microfluidic devices. Hoek, I., Tho, F., Arnold, W.M. Lab. Chip (2010) [Pubmed]
  18. Use of simethicone as a patient preparation for abdominal sonography. Sommer, G., Filly, R.A., Laing, F.C. Radiology. (1977) [Pubmed]
  19. Case report medication error: oral antibiotics and simethicone accidentally injected intravenously. Mahne, R.C., Damen, J., Jansman, F.G. Intensive care medicine. (2003) [Pubmed]
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