Disease relevance of phloretin

• Edema, determined by the edema-disk gravimetric technique, was inhibited in a dose-dependent manner by the intraperitoneally administered prostaglandin antagonists polyphloretin phosphate (PPP) or di-4-phloretin phosphate (DPP) [1].
• Indomethacin, aspirin and polyphloretin phosphate were found to block the epidermal thickening. "Non inflammatory" stretching of the skin induced by a silastic implant caused an increase in the germinative population but no sustained epidermal hyperplasia [2].
• Effect of prostaglandin E1 and polyphloretin phosphate on hemolysis of human erythrocytes [3].
• Polyphloretin phosphate (PPP) suppressed the reaction in controls but in patients with urticaria it increased the reactions to Trafuril and had little effect on the kallikrein reaction [4].

High impact information on phloretin

• The hemolysate contracted basilar arteries in a concentration-dependent fashion, the response being attenuated by treatment with either aspirin or polyphloretin phosphate, a prostaglandin antagonist [5].
• At low concentrations of the two agents, their effects were additive, but they seemed to initiate their effects via different receptors, since polyphloretin phosphate inhibited the effect of TSH but not that of VIP [6].
• Polyphloretin phosphate (PPP) is known to be an inhibitor of bovine TSH (bTSH)-induced stimulation of the thyroid in both in vivo and in vitro assays [7].
• Effect of polyphloretin phosphate on force and heat production in frog sartorius [8].
• The potencies of polyphloretin phosphate, di-4-phloretin phosphate, 4-phloretin phosphate and phloretin to inhibit the stimulation of cAMP accumulation by prostaglandins, isoproterenol and adenosine were studied in 2 clonal cell lines of CNS origin [9].

Anatomical context of phloretin

• Several contractile responses of longitudinal muscles of the guinea-pig digestive tract to exogenously applied ATP (10-300 micrometer), including "rebound" contractions, were inhibited by indomethacin (3-20 micrometer) or polyphloretin phosphate (10-100 microgram/ml) [10].
• The character of the antagonism by polyphloretin phosphate of contractions to prostaglandins E1 and F 2alpha in guinea-pig ileum [11].
• The contractile response of cerebral arteries was potentiated by aspirin and attenuated by polyphloretin phosphate [12].
• Effect of polyphloretin phosphate on the response of non-gravid rat uterus to folkloric and standard oxytocics in vitro [13].
• The effect of polyphloretin phosphate on the aqueous flare response to alpha-melanocyte stimulating hormone [14].

Associations of phloretin with other chemical compounds

• The effects of polyphloretin-phosphate (PPP), an inhibitor of prostaglandins (PG), upon the IDT and frequency of different tubal segments, were also explored [15].
• The in vitro effects of PGF2alpha and its metabolites were selectively blocked by polyphloretin phosphate [16].
• 7-oxa-13-prostynoic acid and polyphloretin phosphate as non-specific antagonists of the stimulatory effects of different agents on adenylate cyclase from various tissues [17].
• Antagonistic effect of polyphloretin phosphate and di-4-phloretin phosphate on the contractile responses of guinea-pig gastric muscles to prostaglandin E2 [18].

Gene context of phloretin

• The stimulatory contractile effect of proestrous FF in isolated segments of sow fimbria was antagonized by polyphloretin phosphate (PPP), a PG receptor blocker and by indomethacin, an inhibitor of PG synthesis [19].

Analytical, diagnostic and therapeutic context of phloretin

• Effect of polyphloretin phosphate on the contraceptive action of a polyethylene intrauterine device in rats [20].

References