Disease relevance of Carbazilquinone

• After creation of a pericardial window for pericardial effusion, she received vincristine, then carbazilquinone intravenously as single chemotherapeutic agents based on the chemosensitivity by clonogenic assay of the supraclavicular tumor, but response was not achieved [1].
• No bone marrow depression was observed but an episode of anaphylactic shock attributable to the use of carbazilquinone occurred in 1 out of a total 75 patients [2].
• Although both agents exhibited a significant effect on plasmacytoma X5563 in C3H/He mice to a similar extent, Mitomycin-C was not as effective on lympholeukemia L-1210 and on the lung metastasis of Ehrlich carcinoma in (C57BL/6 X DBA/2)F1 (BDF1) mice as was Carbazilquinone [3].
• As a corollary, Mitomycin-C and Carbazilquinone stimulated oxygen uptake by Ehrlich ascites tumor cells in the presence of glucose that Daunomycin and Adriamycin failed to do so, although the reason for it remains to be elucidated [4].
• Comparative studies of effects of carbazilquinone and mitomycin C on DNA, RNA and protein synthesis of Yoshida sarcoma and Yoshida ascites hepatomas [5].

High impact information on Carbazilquinone

• Alternating immunochemotherapy of advanced gastric carcinoma: a randomized comparison of carbazilquinone and PSK to carbazilquinone in patients with curative gastric resection [6].
• Using a colony-forming technique and 2 human bladder cancer cell lines, T24 and KK-47, the enhanced radioinduced cytotoxicity in combination with 43 degrees C hyperthermia (HPT) or 4 anticancer drugs; bleomycin (BLM), cis-dichlorodiammineplatinum (II) (CDDP), mitomycin C (MMC), carbazilquinone (CQ), has been studied [7].
• On the results of tests performed to establish the drug concentration required to achive a 50% inhibition of cell survival, carbazilquinone was chosen for the prevention of recurrences of bladder cancer [2].

Anatomical context of Carbazilquinone

• Anticancer drug sensitivity in vitro in the bladder cancer cell line, KK-47 and prophylactic use of carbazilquinone and urokinase in bladder cancer [2].

Analytical, diagnostic and therapeutic context of Carbazilquinone

• The 2 groups were subjected to prophylactic combined intravesical instillation therapy with carbazilquinone and urokinase [2].

References