Disease relevance of Cefadyl

• It appeared to be comparable in therapeutic efficacy to procaine penicillin and cephazolin in the treatment of patients with community-acquired pneumonia, to cephazolin in the treatment of skin and soft tissue infections due to S. aureus or beta-haemolytic streptococci and to cefapirin in S. aureus endocarditis in parenteral drug abusers [1].
• Sodium cephapirin was administered (10 mg/kg of body weight, IM) at 8-hour intervals in 4 consecutive doses to each of 6 lactating dairy cows [2].
• Co-administration of 2 mg of rBoIL-2 and sodium cephapirin in cows with established S. aureus mastitis decreased SCC and shedding of S. aureus compared with values from cows that were given only sodium cephapirin or 10 mg rBoIL-2 with sodium cephapirin [3].

High impact information on Cefadyl

• A specific, stability-indicating, high-performance liquid chromatographic assay was developed for the determination of cephapirin, desacetyl cephapirin and cephapirin lactone in sodium cephapirin (cefadyl) bulk and injectables [4].
• Six calves with suppurative arthritis were given a single IM injection of sodium cephapirin at a dosage of 10 mg/kg of body weight [5].
• Pharmacokinetics of sodium cephapirin in lactating dairy cows [2].
• The renal transport of cefapirin has been assessed in thirteen patients after one dose of 1.0 g i.m. In normal glomerular filtration rate, approximately 50-60% of the dose is recovered in the urine in active form [6].

Chemical compound and disease context of Cefadyl

• Six healthy adult horse mares were each given a single injection of sodium cephapirin (20 mg/kg of body weight, IV), and serum cephapirin concentrations were measured serially over a 6-hour period [7].

Analytical, diagnostic and therapeutic context of Cefadyl

• A 15 min i.v. infusion supplying either 1 or 2 g of sodium cephapirin was administered preoperatively to patients about to undergo either retropubic or transvesical prostatectomy [8].

References