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Chemical Compound Review:

SureCN229650 phenyl-pyridin-4-yl-methanone

Synonyms: NSC-9488, AG-D-89425, ACMC-209cv7, ANW-20945, NSC9488, ...

Shimada, H. et al., Inazu, N. et al., Inaba, N. et al., Busby, M. et al., Imamura, Y. et al., et al.

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High impact information on gamma-Benzoylpyridine

We have recently purified a tetrameric carbonyl reductase from the cytosolic fraction of pig heart (pig heart carbonyl reductase, PHCR), using 4-benzoylpyridine (4-BP) as the substrate [1].
9,10-phenanthrenequinone, a component of diesel exhaust particles, inhibits the reduction of 4-benzoylpyridine and all-trans-retinal and mediates superoxide formation through its redox cycling in pig heart [1].
Ovarian carbonyl reductase activity towards 13,14-dihydro-15-keto-PGF2 alpha (15KD-PGF2 alpha), 4-benzoylpyridine (4BP) and menadione was determined photometrically and radiochemically, and quantitation of ovarian carbonyl reductase content was performed by Western blot analysis [2].
The activities of reduction of 13,14-dihydro-15-keto-PGF2 alpha, 4-benzoylpyridine and menadione in ovarian cytosol were significantly decreased by antiestrogen treatments, and the ovulation was completely inhibited [3].
In this study, carbonyl reductase activity was estimated as the ability to reduce 4-benzoylpyridine to S(-)-alpha-phenyl-4-pyridylmethanol in the cytosolic fraction from pig heart (pig heart cytosol) [4].

Biological context of gamma-Benzoylpyridine

We also propose the possibility that myristic acid at low concentrations inhibits the reduction of 4BP by interacting with a binding site other than the coenzyme- and substrate-binding sites of RHCR [5].
The CR activity (4-benzoylpyridine reducing activity) in the preovulatory mature large follicles did not change between 1500 h and 1900 h on the day of proestrus [6].

Gene context of gamma-Benzoylpyridine

Three enzyme forms (CR1, CR2 and CR3) of carbonyl reductase were purified from chicken liver with using 4-benzoylpyridine as a substrate [7].

Analytical, diagnostic and therapeutic context of gamma-Benzoylpyridine

The lowest allowed electronic transition of fac-[Re(Cl)(CO)(3)(bopy)(2)] (bopy = 4-benzoylpyridine) has a Re --> bopy MLCT character, as revealed by UV-vis and stationary resonance Raman spectroscopy [8].

References

9,10-phenanthrenequinone, a component of diesel exhaust particles, inhibits the reduction of 4-benzoylpyridine and all-trans-retinal and mediates superoxide formation through its redox cycling in pig heart. Shimada, H., Oginuma, M., Hara, A., Imamura, Y. Chem. Res. Toxicol. (2004) [Pubmed]
Regulation of ovarian carbonyl reductase mediated by estrogen receptor in immature rats. Inazu, N., Inaba, N., Satoh, T. Biochem. Pharmacol. (1990) [Pubmed]
Effects of antiestrogens on ovarian aldo-keto reductase in relation to ovulation in rats. Inaba, N., Inazu, N., Kogo, H., Satoh, T. Jpn. J. Pharmacol. (1991) [Pubmed]
Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones. Imamura, Y., Narumi, R., Shimada, H. J Enzyme Inhib Med Chem (2007) [Pubmed]
Inhibition of rabbit heart carbonyl reductase by fatty acids. Imamura, Y., Migita, T., Anraku, M., Otagiri, M. Biol. Pharm. Bull. (1999) [Pubmed]
Pre- and post-ovulatory changes in carbonyl reductase in ovarian follicles and corpora lutea in rats. Inazu, N., Fujii, T. Res. Commun. Mol. Pathol. Pharmacol. (1997) [Pubmed]
Characterization of multiple forms of carbonyl reductase from chicken liver. Nishinaka, T., Kinoshita, Y., Terada, N., Terada, T., Mizoguchi, T., Nishihara, T. Enzyme (1992) [Pubmed]
Rhenium-to-benzoylpyridine and rhenium-to-bipyridine MLCT excited states of fac-[Re(Cl)(4-benzoylpyridine)(2)(CO)(3)] and fac-[Re(4-benzoylpyridine)(CO)(3)(bpy)](+): a time-resolved spectroscopic and spectroelectrochemical study. Busby, M., Matousek, P., Towrie, M., Clark, I.P., Motevalli, M., Hartl, F., Vlcek, A. Inorganic chemistry. (2004) [Pubmed]

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