High impact information on AIDS022106

• When 2-mercaptopyridine was used as a ligand, the difference in conductivity for eluting open circular and supercoiled plasmid DNA is only 6 mS/cm [1].
• Ni2+ forms a lipophilic complex with pyridinethione and it can be assumed that a facilitated passage of the Ni2+ across the cellular membranes of various tissues is important for the observed effects [2].
• Pigmented tissues (e.g. the eye melanin), the pancreatic islets, the nervous system and striated muscles showed high levels of Ni2+ in animals given sodium pyridinethione [2].
• In the ferret sodium pyridinethione induced a high uptake of Ni2+ in the heart muscle, which was not seen in the other species [2].
• In this synthesis the Z group was removed by transfer hydrogenation and the Nps group by treatment with 2-thiopyridone [3].

Anatomical context of AIDS022106

• For 63Ni2+ the sodium pyridinethione induced a strong labelling of the pancreatic islets and of the melanin of pigmented tissues [4].

Associations of AIDS022106 with other chemical compounds

• All 3 metals were shown to form lipophilic complexes with pyridinethione (the nickel and zinc complexes being more lipophilic than the cadmium complex) and a facilitated penetration of the complexed metals through the cellular membranes is probably important for the observed results [4].

Analytical, diagnostic and therapeutic context of AIDS022106

• The gas phase and solvent dependent preference of the tautomerization between 2-pyridinethiol (2SH) and 2-pyridinethione (2S) has been assessed using variable temperature Fourier transform infrared (FTIR) experiments, as well as ab initio and density functional theory computations [5].
• Oral administration of sodium pyridinethione together with 63Ni2+, 109Cd2+ or 65Zn2+ to non-pregnant mice resulted in very markedly increased levels of the metals in several tissues in comparison with animals given the metals alone [4].

References