Disease relevance of Levoglucosan

• Detection of activities of levoglucosan kinase in the cell extracts indicated that levoglucosan kinase gene (lgk) was expressed by the recombinant strain of E. coli DH5alpha [1].
• Levoglucosan dehydrogenase involved in the assimilation of levoglucosan in Arthrobacter sp. I-552 [2].

High impact information on Levoglucosan

• Levoglucosan is a viable tracer for biomass burning aerosols, and the observed products may serve as secondary tracers for these types of aerosols, possibly providing additional information to facilitate source apportionment and better understand atmospheric processing of the aerosol parcel [3].
• Levoglucosan represents the largest single component of the water extractable organics in smoke particles and can be used to trace forest fires or discriminate urban air pollution sources [4].
• Exclusive substrate specificity for levoglucosan suggested that not only the structure of the intramolecular glucosidic linkage but also the configuration of the pyranose frame would be specific for recognition by levoglucosan kinase [1].
• These results suggest that the m/z 60 ion is an EI fragment ion of levoglucosan, formed by loss of neutral species containing C-1 [5].
• A complex of 1,6-anhydro-beta-maltose with rubidium and that of 1,6-anhydro-beta-D-glucopyranose with rubidium were characterized using 87Rb NMR spectroscopy, diffusion-ordered NMR spectroscopy (DOSY) and electrospray ionization mass spectrometry (ESI-MS) [6].

Biological context of Levoglucosan

• A molecular tracer of biomass combustion, the sugar levoglucosan is abundant and constitutes a remarkably narrow PM2.5 mass range (2.8-3.6%) [7].
• The levoglucosan prepared was fermented to citric acid by Aspergillus niger CBX-209, which was a mutant derived by gamma-ray mutagenesis of the parent strain CBX-2 [8].

Associations of Levoglucosan with other chemical compounds

• Mass ratios between the biomass burning tracers studied were found to be significantly different (e.g., beta-sitosterol to nssK+ ratios were more than three times higher in Christchurch than in Auckland), although levoglucosan to nssK+ ratios were similar at the both sites [9].
• Three patterns of carbon number distributions of alkyl amides varied with location and time, and were mainly impacted by biomass burning or cooking compared to levoglucosan and cholesterol in the LFV [10].
• In an effort to determine the effect of biomass burning on PM2.5 concentrations, samples during 2000 were analyzed for levoglucosan, palmitic acid, and stearic acid [11].

Analytical, diagnostic and therapeutic context of Levoglucosan

• Determination of levoglucosan in atmospheric aerosols using high performance liquid chromatography with aerosol charge detection [12].
• Determination of levoglucosan from smoke samples using microchip capillary electrophoresis with pulsed amperometric detection [4].
• Twenty-two methoxyphenols, levoglucosan, and 17 polynuclear hydrocarbons were quantified by gas chromatography/mass spectrometry assays for personal filter samples and urine samples [13].
• A sensitive method for analysis of levoglucosan (1,6-anhydro-beta,d-glucopyranose) and other monosaccharide anhydrides, compounds present in biomass combustion smoke, was investigated employing high-performance liquid chromatography (HPLC) with recently developed aerosol charge detection [12].
• On hydrogen bonding in 1,6-anhydro-beta-D-glucopyranose (levoglucosan): X-ray and neutron diffraction and DFT study [14].

References