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Chemical Compound Review:

Hinesol 2-(6,10- dimethylspiro[4.5]dec-9-en- 2...

Synonyms: Agarospirol, Agaruspirol, AGN-PC-007X6N, AG-J-68307, NSC-152472, ...

Satoh, K. et al., Takeda, O. et al., Okugawa, H. et al., Hashimoto, T. et al.

Satoh, Nagai, Kano,

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High impact information on Hinesol

The activity of K+-dependent p-nitrophenyl phosphatase (K+-pNPPase), a partial reaction of H+,K+-ATPase, was inhibited by hinesol noncompetitively with respect to pNPP (IC50 value of 1.6x10(-4) M), and competitively with respect to K+, whereas it was not affected by the Mg2+ concentration [1].
After two or three years' cultivation, main essential oil components, i.e., the sesquiterpenes: elemol ( 1), atractylon ( 2), hinesol ( 3), beta -eudesmol ( 4), selina-4(14),7(11)-dien-8-one ( 5), and the polyacetylene of atractylodin ( 6) were determined by capillary gas chromatography [2].
Effect of jinkoh-eremol and agarospirol from agarwood on the central nervous system in mice [3].
Biotransformation of hinesol isolated from the crude drug Atractylodes lancea by Aspergillus niger and Aspergillus cellulosae [4].

Biological context of Hinesol

Hinesol, a major component of the crude drug "So-jutsu" (Atractylodis Lanceae Rhizoma), strongly inhibited H+,K+-ATPase activity with a IC50 value of 5.8x10(-5) M [1].

Analytical, diagnostic and therapeutic context of Hinesol

By repeated fractionation, oral administration in mice, and pharmacological screening, the active principles, jinkoh-eremol and agarospirol, were obtained from the benzene extract [3].

References

Inhibition of H+,K+ -ATPase by hinesol, a major component of So-jutsu, by interaction with enzyme in the E1 state. Satoh, K., Nagai, F., Kano, I. Biochem. Pharmacol. (2000) [Pubmed]
A Comparative Study on Essential Oil Components of Wild and Cultivated Atractylodes lancea and A. chinensis. Takeda, O., Miki, E., Terabayashi, S., Okada, M., Lu, Y., He, H.S., He, S.A. Planta Med. (1996) [Pubmed]
Effect of jinkoh-eremol and agarospirol from agarwood on the central nervous system in mice. Okugawa, H., Ueda, R., Matsumoto, K., Kawanishi, K., Kato, A. Planta Med. (1996) [Pubmed]
Biotransformation of hinesol isolated from the crude drug Atractylodes lancea by Aspergillus niger and Aspergillus cellulosae. Hashimoto, T., Noma, Y., Kato, S., Tanaka, M., Takaoka, S., Asakawa, Y. Chem. Pharm. Bull. (1999) [Pubmed]

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