Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Cyclopropavir 2-amino-9-[(Z)-[2,2- bis(hydroxymethyl)cycl...

Synonyms: ZSM-I-62, ZSM-I62, AC1MHJTJ, ZSM-I 62, MBX-400, ...

Kern, E.R. et al., Kern, E.R. et al., Kern, E.R. et al.

Kern, Kushner, Hartline, Williams-Aziz, Harden, Zhou, Zemlicka, Prichard, Kern, Kern, Bidanset, Hartline, Yan, Zemlicka, Quenelle,

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Disease relevance of AIDS165691

One of these, ZSM-I-62, had particularly good activity against CMV, HHV-6, and HHV-8, with EC(50)s of 0.7 to 8 microM [1].
A second-generation analog, (Z)-9-[[2,2-bis-(hydroxymethyl)cyclopropylidene]methyl]guanine (ZSM-I-62, cyclopropavir [CPV]), has particularly good activity against murine and human cytomegaloviruses (MCMV and HCMV) in vitro [2].

High impact information on AIDS165691

The SCID-hu mouse models in which human tissue is infected with human CMV has been very useful in the development of new antiviral agents such as maribavir and cyclopropavir [3].

References

In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Kern, E.R., Kushner, N.L., Hartline, C.B., Williams-Aziz, S.L., Harden, E.A., Zhou, S., Zemlicka, J., Prichard, M.N. Antimicrob. Agents Chemother. (2005) [Pubmed]
Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections. Kern, E.R., Bidanset, D.J., Hartline, C.B., Yan, Z., Zemlicka, J., Quenelle, D.C. Antimicrob. Agents Chemother. (2004) [Pubmed]
Pivotal role of animal models in the development of new therapies for cytomegalovirus infections. Kern, E.R. Antiviral Res. (2006) [Pubmed]

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