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Chemical Compound Review:

FR-900452 (3S)-1-methyl-3-[(1S)-1- [(2S,3E,5S)-5...

Synonyms: AC1MI03V, FR 900452, WS 7739 B

Okamoto, M. et al., Man, R.Y. et al., Okamoto, M. et al., Okamoto, M. et al., Hu, W. et al.

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Disease relevance of FR-900452

In contrast, FR-900452 did not reduced the leukopenia at any time of after endotoxin [1].
A PAF antagonist, designated as FR-900452, was isolated from fermentation products of Streptomyces phaeofaciens and the molecular formula was determined as C22H25N3O3S [2].
Therefore, in order to determine whether endogenous PAF contributes to the occurrence of thrombocytopenia or leukopenia in endotoxin shock, we assessed the effect of FR-900452 on the thrombocytopenia and the leukopenia following bolus i.v. injection of E.coli endotoxin (0.03 mg/kg) in rabbits [1].

High impact information on FR-900452

Pretreatment with FR-900452 (a PAF receptor antagonist) or MK-886 (a leukotriene synthesis inhibitor) significantly reduced the vasodilator and vasoconstrictor effects of H-PAF and E-PAF [3].
Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models [4].

Associations of FR-900452 with other chemical compounds

The vasoconstrictor actions of WEB 2086 and WEB 2170 were not observed with a structurally different PAF receptor antagonist, FR-900452 [5].

References

Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. Okamoto, M., Yoshida, K., Nishikawa, M., Kohsaka, M., Aoki, H. Thromb. Res. (1986) [Pubmed]
FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. Okamoto, M., Yoshida, K., Nishikawa, M., Ando, T., Iwami, M., Kohsaka, M., Aoki, H. J. Antibiot. (1986) [Pubmed]
Similar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist properties. Man, R.Y., Kinnaird, A.A. Br. J. Pharmacol. (1995) [Pubmed]
Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models. Okamoto, M., Yoshida, K., Nishikawa, M., Hayashi, K., Uchida, I., Kohsaka, M., Aoki, H. Chem. Pharm. Bull. (1986) [Pubmed]
Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart. Hu, W., McNicholl, I.K., Choy, P.C., Man, R.Y. Br. J. Pharmacol. (1993) [Pubmed]

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