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Chemical Compound Review

Abn-cbd     4-[(1R,6R)-3-methyl-6-prop-1- en-2-yl-1...

Synonyms: AC1MHZSC, LS-143407, 78216-32-7, Abnormal cannabidiol, 1-Hydroxy-3-n-pentyl-cannabidiol, ...
 
 
 
 
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Disease relevance of Abn-cbd

 

High impact information on Abn-cbd

  • Abn-cbd-induced vasodilation is also blocked in the presence of charybdotoxin (100 nM) plus apamin (100 nM), a combination of K(+)-channel toxins reported to block the release of an endothelium-derived hyperpolarizing factor (EDHF) [1].
  • In the rat mesenteric arterial bed, Abn-cbd-induced vasodilation is unaffected by blockade of endothelial NO synthase, cyclooxygenase, or capsaicin receptors, but it is abolished by endothelial denudation [1].

References

  1. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Járai, Z., Wagner, J.A., Varga, K., Lake, K.D., Compton, D.R., Martin, B.R., Zimmer, A.M., Bonner, T.I., Buckley, N.E., Mezey, E., Razdan, R.K., Zimmer, A., Kunos, G. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
 
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