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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AC1MIVLR     2-ethoxy-5-methyl-3H- pyrimidin-4-one

Synonyms: 2-Ethylthymine, 25628-75-5, O(2)-Ethylthymine, 2-ethoxy-5-methyl-1H-pyrimidin-6-one, 4(1H)-Pyrimidinone, 2-ethoxy-5-methyl-
 
 
 
 
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High impact information on O(2)-Ethylthymine

  • In mature and immature oocytes, ENU-induced mutations in the vermilion locus were 43.5% A:T-->G:C transitions, 39.1% A:T-->T:A transversions, 8.7% G:C-->A:T transitions, and 8.7% A:T-->C:G transversions, indicating that the most important premutagenic lesions induced by this chemical are O(4)-ethylthymine and O(2)-ethylthymine [1].

References

  1. O-ethylthymidine adducts are the most relevant damages for mutation induced by N-ethyl-N-nitrosourea in female germ cells of Drosophila melanogaster. Alvarez, L., Comendador, M.A., Sierra, L.M. Environ. Mol. Mutagen. (2002) [Pubmed]
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