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Chemical Compound Review:

Icosanoyl-CoA [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-4...

Synonyms: Arachidoyl-coa, Eicosanoyl-CoA, AC1MIWXA, CHEBI:15527, C02041, ...

Yoshida, S. et al., Yoshida, S. et al., Suneja, S.K. et al., Yoshida, S. et al., Jeong, J.Y. et al., et al.

Jeong, Johns, Sinclair, Park, Rossie,

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High impact information on Arachidoyl-coenzyme A

Using long-chain fatty acyl CoAs (arachidoyl CoA and behenoyl CoA), a decrease in overall fatty acid chain elongation activity was observed in the quaking and jimpy mouse brain microsomes relative to controls [1].
The elongation of arachidoyl-CoA (20:0-CoA) yielded 22:0 and 24:0 concomitantly, whereas the elongation of behenoyl-CoA (22:0-CoA) yielded only a negligible amount of 24:0 in adult swine cerebral microsomes [2].
Dephosphorylation of 32P-MBP, but not 32P-casein, was stimulated by unsaturated fatty acids and by arachidoyl coenzyme A. Limited proteolysis of Ppt1p removed the TPR domain and abrogated lipid stimulation [3].
The elongation of endogenous palmitoyl-CoA to stearate was highly active in both cerebral and liver microsomes, whereas those of arachidoyl-CoA (20:0-CoA) and endogenous arachidonoyl-CoA (20:4-CoA) were high in cerebral microsomes, but negligible in liver microsomes [4].

Analytical, diagnostic and therapeutic context of Arachidoyl-coenzyme A

The condensation and overall elongation products of exogenous arachidoyl-CoA (20:0-CoA) and endogenous fatty acids in swine cerebral microsomes were detected by radio gas chromatography [5].
The condensation products in the elongation of exogenous arachidoyl-CoA (20:0-CoA) and endogenous fatty acids in adult swine cerebral microsomes were isolated and purified by using HPLC and a radioanalyzer [6].

References

Decreased long-chain fatty acyl CoA elongation activity in quaking and jimpy mouse brain: deficiency in one enzyme or multiple enzyme activities? Suneja, S.K., Nagi, M.N., Cook, L., Cinti, D.L. J. Neurochem. (1991) [Pubmed]
Characteristics of synthesis of very-long-chain saturated and tetraenoic fatty acids in swine cerebral microsomes. Yoshida, S., Takeshita, M. J. Neurochem. (1986) [Pubmed]
Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5. Jeong, J.Y., Johns, J., Sinclair, C., Park, J.M., Rossie, S. BMC Cell Biol. (2003) [Pubmed]
Arachidoyl- and arachidonoyl-CoA elongation mechanism in swine cerebral microsomes. Yoshida, S., Takeshita, M. Biochim. Biophys. Acta (1984) [Pubmed]
Comparison between condensation and overall chain elongation of arachidoyl-CoA and arachidonoyl-CoA in swine cerebral microsomes. Yoshida, S., Takeshita, M. Arch. Biochem. Biophys. (1987) [Pubmed]
Analysis of the condensation step in elongation of very-long-chain saturated and tetraenoic fatty acyl-CoAs in swine cerebral microsomes. Yoshida, S., Takeshita, M. Arch. Biochem. Biophys. (1987) [Pubmed]

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