Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1MIYSY 4-[2-[3-[[(2R)-4- [[[(2R,3S,4R,5R)-5-(6...

Synonyms: AG-F-21264, CTK4H3861, 35192-10-0, 3-Hydroxyglutaryl-coa, 3-Hydroxyglutaryl-coenzyme A, ...

Fu, Z. et al., Kramer, P.R. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on 3-Hydroxyglutaryl-coenzyme A

In the observed structure, this residue interacts with a carboxyl group of 3-hydroxyglutarate, the hydrolysis product of the competitive inhibitor 3-hydroxyglutaryl-CoA required for crystallization of human enzyme [1].
While 3-hydroxyglutaryl-CoA does not appear to be a substrate for HMG-CoA lyase, it competitively inhibits both the cleavage reaction (Ki = 50 microM) and the tritium exchange from acetyl-CoA (Ki = 95 microM) [2].

References

Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria. Fu, Z., Runquist, J.A., Forouhar, F., Hussain, M., Hunt, J.F., Miziorko, H.M., Kim, J.J. J. Biol. Chem. (2006) [Pubmed]
3-hydroxy-3-methylglutaryl-CoA lyase: catalysis of acetyl coenzyme A enolization. Kramer, P.R., Miziorko, H.M. Biochemistry (1983) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share