Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1MIZA6 [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-2...

Synonyms: Ac(S)Coa, Acetyldithio-coenzyme A, Coenzyme A, acetyldithio-, Coenzyme A, S-ethanedithioate

Wang, C.Z. et al., Anderson, V.E. et al., Wlassics, I.D. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Acetyldithio-coenzyme A

This failure is attributed to the inability demonstrated in this study of acetyldithio-CoA to thioacetylate the active site Cys89 of the Zoogloea ramigera thiolase [1].
Mutations of this invariant residue (avian enzyme E95A and E95Q; Staphylococcus aureus enzyme E79Q) correlated with diminished ability to catalyze enolization of acetyldithio-CoA [2].

High impact information on Acetyldithio-coenzyme A

Utility of acetyldithio-CoA in detecting the influence of active site residues on substrate enolization by 3-hydroxyl-3-methylglutaryl-CoA synthase [2].
The reaction of acetyldithio-CoA, a readily enolized analog of acetyl-CoA with thiolase from Zoogloea ramigera [1].
Citrate synthase stabilizes the enethiolate of acetyldithio coenzyme A [3].

References

The reaction of acetyldithio-CoA, a readily enolized analog of acetyl-CoA with thiolase from Zoogloea ramigera. Anderson, V.E., Bahnson, B.J., Wlassics, I.D., Walsh, C.T. J. Biol. Chem. (1990) [Pubmed]
Utility of acetyldithio-CoA in detecting the influence of active site residues on substrate enolization by 3-hydroxyl-3-methylglutaryl-CoA synthase. Wang, C.Z., Misra, I., Miziorko, H.M. J. Biol. Chem. (2004) [Pubmed]
Citrate synthase stabilizes the enethiolate of acetyldithio coenzyme A. Wlassics, I.D., Anderson, V.E. Biochemistry (1989) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share