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Chemical Compound Review:

Partricin 33-[(2S,3R,4R,5R,6S)-4-amino- 3,5-dihydroxy...

Synonyms: Partricina, Partricine, Partricinum, SPA-S-132, Spa-S 132, ...

Tweit, R.C. et al., Rimaroli, C. et al., Luna, T. et al.

Rimaroli, Bonabello, Sala, Bruzzese,

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Disease relevance of SPA-S-132

Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis [1].

High impact information on SPA-S-132

Pharmacokinetics and tissue distribution of a new partricin A derivative (N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate) in mice [2].

Analytical, diagnostic and therapeutic context of SPA-S-132

Partricin, a heptaene macrolide antibiotic, has been separated into three polyene components, partricins A, B and C, and one non-polyene component by countercurrent distribution [3].

References

Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis. Luna, T., Mazzolla, R., Romanò, G., Blasi, E. Antimicrob. Agents Chemother. (1997) [Pubmed]
Pharmacokinetics and tissue distribution of a new partricin A derivative (N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate) in mice. Rimaroli, C., Bonabello, A., Sala, P., Bruzzese, T. Journal of pharmaceutical sciences. (2002) [Pubmed]
Characterization of the antifungal and antiprotozoal antibiotic partricin and structural studies on partricins A and B. Tweit, R.C., Pandey, R.C., Rinehart, K.L. J. Antibiot. (1982) [Pubmed]

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