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Chemical Compound Review:

LS-30675 2-[cyclopropylmethyl-(6,7- dimethoxy-1,2,3...

Synonyms: AC1MJ8VD, 116680-67-2

This record was replaced with 3087835.

Ceremuzynski, L. et al., Kasper, W. et al., Tritthart, H.A. et al., Löllgen, H. et al., Arnold, A.E. et al., et al.

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Disease relevance of 2-[cyclopropylmethyl-(6,7-dimethoxytetralin-2-yl)amino]-1-phenyl-ethanol

The aim of this study was to investigate the effectiveness of ST 567 in patients suffering from ischaemic heart disease and to compare the effects of this drug with those of propranolol [1].
Effect of ST-567 (a specific bradycardiac agent) in patients with unstable angina and myocardial infarction [2].
Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure [3].
The effect of Alinidine (ST 567) on hemodynamics at rest and during exercise was studied in subjects with angiographically documented coronary artery disease and left ventricular dysfunction [4].

High impact information on 2-[cyclopropylmethyl-(6,7-dimethoxytetralin-2-yl)amino]-1-phenyl-ethanol

Heart rate at rest was decreased by ST 567 from 76 to 65 (P less than 0.005) by propranolol from 76 to 62 (P less than 0.001) [1].
Exercise tolerance was increased by ST 567 from 20 X 10(3) to 34 X 10(3) J (P less than 0.05), by propranolol from 26 X 10(3) to 32 X 10(3) J (P less than 0.01) (mean values) [1].
Alinidine (ST 567, N-Allyl-Clonidine) exerted concentration-dependent negative chronotropic effects in isolated, spontaneously-beating sinus node cells and Purkinje fibres of guinea pigs and in ventricular strips of chick embryonic myocardium [5].
The corrected sinus node recovery time was unaffected by ST 567 in Group I and increased from 165 +/- 50 to 427 +/- 117 msec in group II [6].
The sinoatrial conduction time was unaffected by ST 567 in group I. The effective refractory period of the right atrium, the atrioventricular node and the right ventricle, as well as the functional refractory period of the atrioventricular node, were unaffected by ST 567 in patients without autonomic blockade [6].

Biological context of 2-[cyclopropylmethyl-(6,7-dimethoxytetralin-2-yl)amino]-1-phenyl-ethanol

Thus, although normal therapeutic plasma levels were achieved, ST 567 demonstrated negative inotropic properties independent of changes in heart rate with this scheme of administration [7].

References

ST 567 compared with propranolol in stable angina. Ceremuzynski, L., Nartowicz, E., Dluzniewski, M., Perkowicz, J., Czarnecki, W., Burduk, P., Budaj, A., Bednarz, B., Chamiec, T., Jurgiel, R. Eur. Heart J. (1987) [Pubmed]
Effect of ST-567 (a specific bradycardiac agent) in patients with unstable angina and myocardial infarction. Simoons, M.L. Eur. Heart J. (1987) [Pubmed]
Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure. Koenig, W., Stauch, M., Sund, M., Wanjura, D., Henze, E. Am. Heart J. (1990) [Pubmed]
[Hemodynamic actions on alinidine during exercise in patients with coronary artery disease.]. Löllgen, H., Just, H., Wollschläger, H., Kersting, F. Zeitschrift für Kardiologie. (1981) [Pubmed]
The effects of the bradycardia-producing compound alinidine on action potentials and tension development in cardiac fibres. Tritthart, H.A., Windisch, H., Heuberger, S. Naunyn Schmiedebergs Arch. Pharmacol. (1981) [Pubmed]
Clinical electrophysiological properties of N-allyl-clonidine (ST 567) in man. Kasper, W., Meinertz, T., Treese, N., Kersting, F., Pop, T., Jähnchen, E. J. Cardiovasc. Pharmacol. (1981) [Pubmed]
Assessment of the bradycardic and inotropic properties of ST 567 using a new scheme of administration. Arnold, A.E., Soward, A.L., Meij, S.H., van Es, G.A., Serruys, P.W. Eur. Heart J. (1987) [Pubmed]

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