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Chemical Compound Review

AGN-PC-00FBCU     (2,3,4-trihydroxy-3-methyl...

Synonyms: AG-K-66597, CTK8A1456, AC1L18BM, 2-C-Methylerythritol 4-phosphate
 
 
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Disease relevance of MEP

 

High impact information on MEP

 

Chemical compound and disease context of MEP

 

Biological context of MEP

 

Anatomical context of MEP

 

Associations of MEP with other chemical compounds

 

Gene context of MEP

 

Analytical, diagnostic and therapeutic context of MEP

References

  1. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Takahashi, S., Kuzuyama, T., Watanabe, H., Seto, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Lethal mutations in the isoprenoid pathway of Salmonella enterica. Cornish, R.M., Roth, J.R., Poulter, C.D. J. Bacteriol. (2006) [Pubmed]
  3. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. Altincicek, B., Moll, J., Campos, N., Foerster, G., Beck, E., Hoeffler, J.F., Grosdemange-Billiard, C., Rodríguez-Concepción, M., Rohmer, M., Boronat, A., Eberl, M., Jomaa, H. J. Immunol. (2001) [Pubmed]
  4. Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues. Kuzuyama, T., Takahashi, S., Takagi, M., Seto, H. J. Biol. Chem. (2000) [Pubmed]
  5. Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. Carretero-Paulet, L., Ahumada, I., Cunillera, N., Rodríguez-Concepción, M., Ferrer, A., Boronat, A., Campos, N. Plant Physiol. (2002) [Pubmed]
  6. Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. Richard, S.B., Lillo, A.M., Tetzlaff, C.N., Bowman, M.E., Noel, J.P., Cane, D.E. Biochemistry (2004) [Pubmed]
  7. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. Campos, N., Rodríguez-Concepción, M., Sauret-Güeto, S., Gallego, F., Lois, L.M., Boronat, A. Biochem. J. (2001) [Pubmed]
  8. Ubiquinone biosynthesis in microorganisms. Meganathan, R. FEMS Microbiol. Lett. (2001) [Pubmed]
  9. fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. Puan, K.J., Wang, H., Dairi, T., Kuzuyama, T., Morita, C.T. FEBS Lett. (2005) [Pubmed]
  10. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening. Rodríguez-Concepción, M., Ahumada, I., Diez-Juez, E., Sauret-Güeto, S., Lois, L.M., Gallego, F., Carretero-Paulet, L., Campos, N., Boronat, A. Plant J. (2001) [Pubmed]
  11. Molecular cloning and expression profile analysis of Ginkgo biloba DXS gene encoding 1-deoxy-D-xylulose 5-phosphate synthase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. Gong, Y.F., Liao, Z.H., Guo, B.H., Sun, X.F., Tang, K.X. Planta Med. (2006) [Pubmed]
  12. Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase. Kemp, L.E., Bond, C.S., Hunter, W.N. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
  13. Analysis of the expression of CLA1, a gene that encodes the 1-deoxyxylulose 5-phosphate synthase of the 2-C-methyl-D-erythritol-4-phosphate pathway in Arabidopsis. Estévez, J.M., Cantero, A., Romero, C., Kawaide, H., Jiménez, L.F., Kuzuyama, T., Seto, H., Kamiya, Y., León, P. Plant Physiol. (2000) [Pubmed]
  14. Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli. Campos, N., Rodríguez-Concepción, M., Seemann, M., Rohmer, M., Boronat, A. FEBS Lett. (2001) [Pubmed]
  15. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. Hintz, M., Reichenberg, A., Altincicek, B., Bahr, U., Gschwind, R.M., Kollas, A.K., Beck, E., Wiesner, J., Eberl, M., Jomaa, H. FEBS Lett. (2001) [Pubmed]
  16. Essential role of residue H49 for activity of Escherichia coli 1-deoxy-D-xylulose 5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid Synthesis. Querol, J., Rodríguez-Concepción, M., Boronat, A., Imperial, S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  17. High-performance liquid chromatography assay for 1-deoxy-D-xylulose 5-phosphate synthase activity using fluorescence detection. Han, Y.S., Sabbioni, C., van der Heijden, R., Verpoorte, R. Journal of chromatography. A. (2003) [Pubmed]
 
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