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Chemical Compound Review

AGN-PC-00FBCU     (2,3,4-trihydroxy-3-methyl...

Synonyms: AG-K-66597, CTK8A1456, AC1L18BM, 2-C-Methylerythritol 4-phosphate
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Disease relevance of MEP


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Chemical compound and disease context of MEP


Biological context of MEP


Anatomical context of MEP


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Gene context of MEP


Analytical, diagnostic and therapeutic context of MEP


  1. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Takahashi, S., Kuzuyama, T., Watanabe, H., Seto, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Lethal mutations in the isoprenoid pathway of Salmonella enterica. Cornish, R.M., Roth, J.R., Poulter, C.D. J. Bacteriol. (2006) [Pubmed]
  3. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. Altincicek, B., Moll, J., Campos, N., Foerster, G., Beck, E., Hoeffler, J.F., Grosdemange-Billiard, C., Rodríguez-Concepción, M., Rohmer, M., Boronat, A., Eberl, M., Jomaa, H. J. Immunol. (2001) [Pubmed]
  4. Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues. Kuzuyama, T., Takahashi, S., Takagi, M., Seto, H. J. Biol. Chem. (2000) [Pubmed]
  5. Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. Carretero-Paulet, L., Ahumada, I., Cunillera, N., Rodríguez-Concepción, M., Ferrer, A., Boronat, A., Campos, N. Plant Physiol. (2002) [Pubmed]
  6. Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. Richard, S.B., Lillo, A.M., Tetzlaff, C.N., Bowman, M.E., Noel, J.P., Cane, D.E. Biochemistry (2004) [Pubmed]
  7. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. Campos, N., Rodríguez-Concepción, M., Sauret-Güeto, S., Gallego, F., Lois, L.M., Boronat, A. Biochem. J. (2001) [Pubmed]
  8. Ubiquinone biosynthesis in microorganisms. Meganathan, R. FEMS Microbiol. Lett. (2001) [Pubmed]
  9. fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. Puan, K.J., Wang, H., Dairi, T., Kuzuyama, T., Morita, C.T. FEBS Lett. (2005) [Pubmed]
  10. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening. Rodríguez-Concepción, M., Ahumada, I., Diez-Juez, E., Sauret-Güeto, S., Lois, L.M., Gallego, F., Carretero-Paulet, L., Campos, N., Boronat, A. Plant J. (2001) [Pubmed]
  11. Molecular cloning and expression profile analysis of Ginkgo biloba DXS gene encoding 1-deoxy-D-xylulose 5-phosphate synthase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. Gong, Y.F., Liao, Z.H., Guo, B.H., Sun, X.F., Tang, K.X. Planta Med. (2006) [Pubmed]
  12. Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase. Kemp, L.E., Bond, C.S., Hunter, W.N. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
  13. Analysis of the expression of CLA1, a gene that encodes the 1-deoxyxylulose 5-phosphate synthase of the 2-C-methyl-D-erythritol-4-phosphate pathway in Arabidopsis. Estévez, J.M., Cantero, A., Romero, C., Kawaide, H., Jiménez, L.F., Kuzuyama, T., Seto, H., Kamiya, Y., León, P. Plant Physiol. (2000) [Pubmed]
  14. Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli. Campos, N., Rodríguez-Concepción, M., Seemann, M., Rohmer, M., Boronat, A. FEBS Lett. (2001) [Pubmed]
  15. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. Hintz, M., Reichenberg, A., Altincicek, B., Bahr, U., Gschwind, R.M., Kollas, A.K., Beck, E., Wiesner, J., Eberl, M., Jomaa, H. FEBS Lett. (2001) [Pubmed]
  16. Essential role of residue H49 for activity of Escherichia coli 1-deoxy-D-xylulose 5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid Synthesis. Querol, J., Rodríguez-Concepción, M., Boronat, A., Imperial, S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  17. High-performance liquid chromatography assay for 1-deoxy-D-xylulose 5-phosphate synthase activity using fluorescence detection. Han, Y.S., Sabbioni, C., van der Heijden, R., Verpoorte, R. Journal of chromatography. A. (2003) [Pubmed]
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