Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN1649266 1-[(4-chlorophenyl)-phenyl- methyl]-4...

Synonyms: AC1L1NFF, LS-60174, 24342-55-0, 848-53-3 (Parent), Homochlorcyclizine HCl, ...

This record was replaced with 3627.

Kurai, J. et al., Nishikata, M. et al.

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Disease relevance of Homorestar

A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching [1].

High impact information on Homorestar

A drug lymphocyte stimulation test was positive only for calcium stearate, an additive contained in the homochlorcyclizine hydrochloride tablet [1].
The enantioselective relationship between the pharmacokinetics and hepatic metabolism of homochlorcyclizine hydrochloride (HCZ) was investigated using rats [2].

References

Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication. Kurai, J., Chikumi, H., Kodani, M., Sako, T., Watanabe, M., Miyata, M., Makino, H., Touge, H., Hitsuda, Y., Shimizu, E. Intern. Med. (2006) [Pubmed]
Effect of first-pass metabolism on enantioselective pharmacokinetics after oral administration of (+)-, (-)- and racemic homochlorcyclizine to rats. Nishikata, M., Nakai, A., Fushida, H., Miyake, K., Arita, T., Iseki, K., Miyazaki, K. Biol. Pharm. Bull. (1994) [Pubmed]

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