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Chemical Compound Review

Panaxatriol     4,4,8,10,14-pentamethyl-17- (2,6,6...

Synonyms: NSC-308880, NSC308880, FT-0686672, AC1L73D5, NCI60_002647, ...
 
 
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High impact information on Panaxatriol

  • Total saponins and panaxatriol did not elevate the level of SOD1, but panaxadiol significantly increased SOD1 [1].
  • Determination of panaxadiol and panaxatriol in ginseng and its preparations by capillary supercritical fluid chromatography (SFC) [2].
  • CONCLUSIONS: These results indicate that ginseng saponins, especially PT fraction, have substantial inhibitory effects on the recombinant 5HT(3A) receptor, suggesting that some of the specific types of ginsenoside might have an antagonistic action against 5HT(3A) receptor related to nausea and vomiting [3].
  • These results suggest that GR-induced down-regulation of MMP-9 by PD and PT contributes to reduce the invasive capacity of HT1080 cells [4].
  • The results of the in vitro invasion assay revealed that PD and PT reduced tumor cell invasion through a reconstituted basement membrane in the transwell chamber [4].
 

Biological context of Panaxatriol

References

  1. Transcriptional activation of the Cu,Zn-superoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng. Kim, Y.H., Park, K.H., Rho, H.M. J. Biol. Chem. (1996) [Pubmed]
  2. Determination of panaxadiol and panaxatriol in ginseng and its preparations by capillary supercritical fluid chromatography (SFC). Li, Y.H., Li, X.L., Hong, L., Liu, J.Y., Zhang, M.Y. Biomed. Chromatogr. (1992) [Pubmed]
  3. Effect of ginseng saponins on the recombinant serotonin type 3A receptor expressed in xenopus oocytes: implication of possible application as an antiemetic. Min, K.T., Koo, B.N., Kang, J.W., Bai, S.J., Ko, S.R., Cho, Z.H. Journal of alternative and complementary medicine (New York, N.Y.) (2003) [Pubmed]
  4. Glucocorticoid receptor-induced down-regulation of MMP-9 by ginseng components, PD and PT contributes to inhibition of the invasive capacity of HT1080 human fibrosarcoma cells. Park, M.T., Cha, H.J., Jeong, J.W., Kim, S.I., Chung, H.Y., Kim, N.D., Kim, O.H., Kim, K.W. Mol. Cells (1999) [Pubmed]
  5. Effect of panaxatriol ginsenoside on interleukin-6 mRNA translation. Tian, Z.G., Yang, G.Z., Sun, R., Li, D.H., Zhang, J., Cui, Z.Y. Chin. Med. J. (1991) [Pubmed]
 
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