Disease relevance of NSC8715

• Insect growth regulating (IGR) activity of 29 diphenyl urea compounds was determined against the filariasis vector, Culex quinquefasciatus [1].

High impact information on NSC8715

• Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) [2].
• Computational docking experiments indicate how diphenylurea compounds bind to the plasmepsin active site and inhibit the enzyme [3].
• Here we further show that AHK4 is a primary receptor that directly binds a variety of natural and synthetic cytokinins (e.g. not only N(6)-substituted aminopurines such as isopentenyl-adenine, trans-zeatin, benzyl-adenine, but also diphenylurea derivatives such as thidiazuron), in a highly specific manner (K(d) = 4.55+/-0.48x10(-9) M) [4].
• Some widely used standard protocols for the separation of phenylthiohydantoin amino acid derivatives by reverse-phase gradient HPLC do not provide separation of the phenylthiohydantoin derivative of tryptophan (PTH-Trp) from diphenylurea (DPU), a by-product generated during Edman degradation of proteins in variable amounts [5].

References