Disease relevance of OCTACHLOROSTYRENE

• Influence of iron on the induction of hepatic tumors and porphyria by octachlorostyrene in C57BL/10ScSn mice [1].
• Long-term toxicity of octachlorostyrene in the rat [2].

High impact information on OCTACHLOROSTYRENE

• Induction of liver microsomal cytochrome P-450 and associated monooxygenases by octachlorostyrene in inbred strains of mice. Lack of correlation with the murine Ah locus [3].
• Our findings indicate that metabolic biotransformation is a factor in the bioaccumulation, pharmacokinetics, and fate of OCS and highly chlorinated PCB congeners that are generally more recalcitrant in fish [4].
• The tissue distribution, metabolism, and excretion of octachlorostyrene in the rat [5].
• OCS, HCBD and PCA were detected in biota from Greenland, although at very low concentrations [6].
• Although octachlorostyrene (OCS) was never used as a commercial product, it may be produced during incineration and combustion processes involving chlorinated compounds [7].

Chemical compound and disease context of OCTACHLOROSTYRENE

• Distinction between octachlorostyrene and hexachlorobenzene in their potentials to induce ethoxyphenoxazone deethylase and cause porphyria in rats and mice [8].

Anatomical context of OCTACHLOROSTYRENE

• A gas chromatographic method is described for the analysis of human milk to determine polychlorinated biphenyls (PCBs) as 72 congeners plus p,p'-DDE, mirex, hexachlorobenzene, and octachlorostyrene [9].

Associations of OCTACHLOROSTYRENE with other chemical compounds

• Workers exposed to hexachlorobenzene and octachlorostyrene had a statistically significant increase in urinary total porphyrins, compared with controls (mean +/- standard deviation: 13.63 +/- 11.13 micromol/mol creatinine and 6.24 +/- 3.84 micromol/mol creatinine, respectively; p = .02) [10].
• METHODS: Plasma from nine male aluminium foundry workers with past experience of use of hexachloroethane and 18 controls (two controls per exposed case) matched for residence, sex, age, and socioeconomic status was analysed for hexachlorobenzene (HCB), (P-HCB), and octachlorostyrene (P-OCS) with low resolution gas chromatography-mass spectrometry [11].
• Disposition of phenanthrene and octachlorostyrene in spiny lobsters, Panulirus argus, after intragastric administration [12].
• Fifty-four eel samples from 11 different countries were analysed by capillary gas chromatography for levels of the pesticides aldrin, endrin, hexachlorobenzene, alpha- and beta-BHC, lindane, heptachlor, octachlorostyrene, pp'-DDT, pp'-DDD, pp'-DDE, and for the levels of the PCB congeners 28, 52, 101, 138, 153, and 180 [13].
• Single intraperitoneal injections of 200 mg/kg octachlorostyrene (OCS) increased the activities of flavin-containing monooxygenase, epoxide hydrolase and glutathione S-transferase in the livers of male Wistar rats [14].

Gene context of OCTACHLOROSTYRENE

• Mussels were solvent-extracted and analyzed individually by dual capillary column gas chromatography for seven organochlorine pesticides, 11 chlorobenzenes, octachlorostyrene and 63 PCB congeners [15].

Analytical, diagnostic and therapeutic context of OCTACHLOROSTYRENE

• It was the first time that octachlorostyrene (OCS) (n.d.-9.2 ng/ml) could be detected in Germans. The pollutants were determined by means of capillary gas chromatography and atomic absorption spectroscopy, respectively [16].

References